C. Hicks

ACKR3 Proximity Labeling Identifies Novel G protein- and β-arrestin-independent GPCR Interacting Proteins

The paper identifies novel GPCR interacting proteins independent of G proteins and β-arrestins using proximity labeling in cells lacking β-arrestin.

Mechanism of histone H2B monoubiquitination by Bre1

The paper reveals the mechanism by which Bre1 monoubiquitinates histone H2B, showing how its RING domains position Rad6 and contact DNA, and suggests a general mechanism for histone specificity.

Subcellular localization of GPCR kinases differentially modulate biased signaling at CXCR3

The paper shows GRKs translocate to endosomes after CXCR3 activation, with ligand-specific GRK recruitment affecting biased signaling.

Location bias contributes to functionally selective responses of biased CXCR3 agonists

The paper shows that biased CXCR3 agonists produce different signaling outcomes based on subcellular location, with endosomal signaling playing a key role in biased activation.

The mechanism of cross-talk between histone H2B ubiquitination and H3 methylation by Dot1L

This study reveals how H2B ubiquitination enables Dot1L to methylate H3K79 by inducing a conformational change in histone H3.

Exposure to unpredictable trips and slips while walking can improve balance recovery responses with minimum predictive gait alterations

This study shows that repeated exposure to unpredictable slips and trips improves balance recovery without requiring predictive gait changes.