Author

N. Hoffmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Assay:structural biology· 2 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Wolberger· 2 shared E. J. Worden· 2 shared A. Chenchar· 1 shared B. Knutson· 1 shared C. Hicks· 1 shared E. S. Andersen· 1 shared F. K. Knop· 1 shared I. Jarlhelt· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiophysics

C. Wolberger

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Author profile →

3 papers

Recent·Most cited

Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome

N. Hoffmann, S. Rahman, E. J. Worden, M. L. Smith, K. E. Namitz, B. Knutson, M. S. Cosgrove, C. Wolberger

The paper determines structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosomes using cryo-EM and mass spectrometry-crosslinking, revealing multiple states and the role of ubiquitin in complex assembly.

bioRxiv · Apr 4, 2022 · PreprintBiophysics

The mechanism of cross-talk between histone H2B ubiquitination and H3 methylation by Dot1L

E. J. Worden, N. Hoffmann, C. Hicks, C. Wolberger

This study reveals how H2B ubiquitination enables Dot1L to methylate H3K79 by inducing a conformational change in histone H3.

bioRxiv · Dec 22, 2018Biochemistry

FGF21, a liver hormone that inhibits alcohol intake in mice, increases in human circulation after acute alcohol ingestion and sustained binge drinking at Oktoberfest

S. Soeberg, E. S. Andersen, N. B. Dalgaard, I. Jarlhelt, N. L. Hansen, N. Hoffmann, T. Vilsboell, A. Chenchar, M. Jensen, T. J. Grevengoed, S. A. J. Trammell, F. K. Knop, M. P. Gillum

This study shows that alcohol increases FGF21 levels in humans and that FGF21 reduces alcohol intake in mice.

bioRxiv · Feb 13, 2018Physiology