J. George

NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis

This study identifies NSD2 as a critical component of the AR neo-enhanceosome in prostate cancer, showing its role in AR enhancer circuitry and tumor progression.

p300/CBP degradation is required to disable the active AR enhanceosome in prostate cancer

This study shows that degrading p300/CBP in prostate cancer suppresses tumor growth more effectively than inhibiting their activity, highlighting their role in maintaining the active AR enhanceosome.

Single-cell and bulk transcriptional profiling of mouse ovaries reveals novel genes and pathways associated with DNA damage response in oocytes.

The paper uses single-cell and bulk RNA sequencing to study DNA damage response in mouse ovaries, identifying novel genes and pathways specific to oocytes.

Immunosuppressive tumor microenvironment of osteosarcoma

This study identifies immunosuppressive mechanisms in osteosarcoma using single-cell and spatial transcriptomics, revealing interactions between MDSCs, T-cells, and tumor cells that promote an immunosuppressive microenvironment.

Bile acids mediate liver-bone marrow crosstalk

This study shows that bile acid biosynthesis, not liver tumors, drives HSPC responses in mice, with dietary cholesterol enhancing this effect.

Functional synapses between small cell lung cancer and glutamatergic neurons

This study identifies glutamatergic synaptic interactions between SCLC cells and neurons, showing that these interactions support tumor growth and can be targeted therapeutically.

Bird song comparison using deep learning trained from avian perceptual judgments

The paper develops a deep learning method trained on avian perceptual judgments to compare bird song similarity, outperforming existing software and closely matching avian assessments.

Sex-biased Yap1 oncogene function

This study shows that Yap1, an oncogene, has sex-biased functions in medulloblastoma progression and immune suppression, with greater impact in males.

Collaborative partnership model to transform bioinformatics core into a highly effective research partner and multiply the impact

This paper describes a collaborative partnership model that transformed a bioinformatics core into an active research collaborator, enhancing its impact on scientific research.

Cellular Heterogeneity of Pluripotent Stem Cell Derived Cardiomyocyte Grafts is Mechanistically Linked to Treatable Arrhythmias

This study identifies arrhythmogenic subpopulations in pluripotent stem cell-derived cardiomyocytes and shows that combination therapy and catheter ablation can reduce engraftment arrhythmias.

A Genomically and Clinically Annotated Patient Derived Xenograft (PDX) Resource for Preclinical Research in Non-Small Cell Lung Cancer

The paper describes a collection of 79 genomically and clinically annotated lung cancer PDX models that retain patient tumor features and treatment responses, available through MMHCdb.

Arabidopsis CONSERVED BINDING OF EIF4E1 negatively regulates the NADPH oxidase RESPIRATORY BURST OXIDASE HOMOLOG D

The paper identifies CBE1 as a novel regulator of immune signaling in Arabidopsis by controlling RBOHD accumulation and ROS production during plant stress responses.

Concurrent invasions by European starlings (Sturnus vulgaris) suggest selection on shared genomic regions even after genetic bottlenecks

The paper compares whole-genome sequences of European Starlings from native and introduced populations to show that post-bottleneck expansion supports local adaptation through selection on shared genomic regions.

Transcriptomic profiling of fibropapillomatosis in green sea turtles (Chelonia mydas) from South Texas

This study uses transcriptome sequencing to analyze gene expression in fibropapillomatosis tumors and healthy tissue from green sea turtles, identifying human orthologs and potential immune checkpoint targets.

LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency

This study shows that LRG1 promotes tumor vascular dysfunction and suppresses immunotherapy effectiveness, with its inhibition enhancing therapeutic outcomes in mouse cancer models.

A Humanized Antibody against LRG1 that Inhibits Angiogenesis and Reduces Retinal Vascular Leakage

RNA-binding protein FXR1 drives cMYC translation by mRNA circularization through eIF4F recruitment in ovarian cancer

This study identifies FXR1 as a driver of cMYC translation through mRNA circularization and eIF4F recruitment in ovarian cancer, linking FXR1 amplification to poor prognosis.

Perturbation of effector and regulatory T cell subsets in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

This study identifies altered T cell subset frequencies and functions in ME/CFS patients, suggesting chronic immune activation and potential biomarkers.

Differential functions of splicing factors in breast-cancer initiation and metastasis

This study identifies splicing factors involved in breast cancer initiation and metastasis, showing their differential roles and interactions with MYC.

A mechanism-based computational model to capture the interconnections among epithelial-mesenchymal transition, cancer stem cells and Notch-Jagged signaling

The paper develops a computational model to explore the interactions between EMT, CSCs, and Notch-Jagged signaling, revealing how hybrid E/M cells with stemness traits and enhanced Notch-Jagged signaling contribute to therapeutic resistance.