Author

E. Kostenis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 2 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:electrophysiology· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. Bacchin· 1 shared A. Kliewer· 1 shared C. Hoffmann· 1 shared C. Ziegler· 1 shared E. Miess· 1 shared E. S. F. Matthees· 1 shared F. Andres· 1 shared F. Lauber· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiochemistry

A. Bacchin

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Label-free biosensor assay decodes the dynamics of Toll-like receptor signaling

J. Holze, F. Lauber, E. Kostenis, G. Weindl

This paper introduces a label-free optical biosensor assay to study TLR signaling dynamics and identifies pharmacological modulators and previously unrecognized signaling signatures.

bioRxiv · Jan 18, 2024Pharmacology & Toxicology

Cyclic peptide inhibitors stabilize Gq/11 heterotrimers

J. Muehle, M. J. Rodrigues, J. Alenfelder, L. Juergenliemke, R. Guixa-Gonzalez, A. Bacchin, F. Andres, M. Hennig, H. Schihada, M. Cruesemann, G. Koenig, E. Kostenis, G. Schertler, X. Deupi

This study determines the crystal structures of FR and YM bound to G11, revealing they stabilize Gq/11 heterotrimers by reinforcing the G and Gβ interface.

bioRxiv · Oct 24, 2023 · PreprintBiochemistry

GRK2/3/5/6 knockout: The impact of individual GRKs on arrestin-binding and GPCR regulation

J. Drube, R. S. Haider, E. S. F. Matthees, M. Reichel, J. Zeiner, S. Fritzwanker, C. Ziegler, S. Barz, L. Klement, A. Kliewer, E. Miess, E. Kostenis, S. Schulz, C. Hoffmann

This study investigates the role of individual GRKs in GPCR regulation and β-arrestin interactions using GRK knockout cells and identifies distinct GRK-mediated mechanisms.

bioRxiv · Feb 12, 2021Cell Biology

Oxytocin signals via Gi and Gq to drive persistent CA2 pyramidal cell firing and strengthen CA3-CA1 neurotransmission

K. Eyring, J. Liu, G. König, S. Hidema, K. Nishimori, E. Kostenis, R. Tsien

This study shows oxytocin modulates CA2 pyramidal cell firing through Gq and Gi proteins, enhancing CA3-CA1 neurotransmission by affecting interneurons.

bioRxiv · May 7, 2020 · PreprintCell Biology