Author

J. Drube

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. Hoffmann· 5 shared A. Kliewer· 2 shared M. Reichel· 2 shared S. Fritzwanker· 2 shared S. Schulz· 2 shared A. Batista-Gondin· 1 shared A. Godbole· 1 shared A. Inoue· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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5 shared papersPharmacology & Toxicology

C. Hoffmann

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Author profile →

5 papers

Recent·Most cited

Multi-faceted roles of β-arrestins in G protein-coupled receptors endocytosis

J. Liu, L. Xue, M. Ravier, A. Inoue, J. Drube, C. Hoffmann, E. Trinquet, E. Dupuis, L. Prezeau, J.-P. Pin, P. Rondard

The paper challenges the conventional view of GPCR internalization by showing multiple pathways regulate receptor internalization, with specific findings on the GLP-1R's mechanism.

bioRxiv · Jan 18, 2024Cell Biology

Key phosphorylation sites for robust β-arrestin2 binding at the mu-opioid receptor revisited

O. Underwood, S. Frizwanker, J. Glenn, A. Batista-Gondin, J. Drube, C. Hoffmann, S. J. Briddon, S. S. Schulz, M. Canals

The paper investigates the role of GRK subfamilies in phosphorylation of the MOR C-tail and their impact on β-arrestin2 recruitment, showing GRK2/3 and GRK5/6 have distinct contributions.

bioRxiv · Dec 5, 2023 · PreprintPharmacology & Toxicology

GRK specificity and beta gamma dependency determines a GPCR`s potential in biased agonism

E. S. Matthees, J. C. Filor, N. Jaiswal, M. Reichel, N. Youssef, J. Drube, A. Godbole, C. Hoffmann

This paper shows that GRK2/3's interaction with Gβγ is essential for β-arrestin2 recruitment to GPCRs, linking G protein activation to biased agonism potential.

bioRxiv · Jul 14, 2023Pharmacology & Toxicology

A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening

J. Kaufmann, N. K. Blum, F. Nagel, A. S. Anna Schuler, J. Drube, C. Degenhart, J. Engel, J. E. Eickhoff, P. Dasgupta, S. Fritzwanker, M. Guastadisegni, C. Schulte, E. Miess-Tanneberg, H. M. Maric, M. Spetea, , S. Schulz

This paper develops a bead-based immunoassay to quantify GPCR phosphorylation for ligand profiling and GRK inhibitor screening, demonstrating its utility with selective inhibitors.

bioRxiv · Jul 25, 2022Pharmacology & Toxicology

GRK2/3/5/6 knockout: The impact of individual GRKs on arrestin-binding and GPCR regulation

J. Drube, R. S. Haider, E. S. F. Matthees, M. Reichel, J. Zeiner, S. Fritzwanker, C. Ziegler, S. Barz, L. Klement, A. Kliewer, E. Miess, E. Kostenis, S. Schulz, C. Hoffmann

This study investigates the role of individual GRKs in GPCR regulation and β-arrestin interactions using GRK knockout cells and identifies distinct GRK-mediated mechanisms.

bioRxiv · Feb 12, 2021Cell Biology