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9 papers
Recent·Most cited
O. Tejero, F. K. Pamula, M. Koyanagi, T. Nagata, P. Afanasyev, I. Das, X. Deupi, M. Sheves, A. Terakita, G. F. X. Schertler, M. J. Rodrigues, C.-J. Tsai
This study presents active state structures of a bistable opsin, JSR1, bound to G proteins, revealing differences in activation mechanisms between monostable and bistable opsins.
bioRxiv · Apr 9, 2024Biochemistry
J. Wang, D. Beyer, C. Vaccarin, Y. He, M. Tanriver, R. M. Benoit, X. Deupi, L. Mu, J. W. Bode, r. Schibli, C. Mueller
This paper develops and evaluates radiofluorinated derivatives of MLN-4760 for PET imaging of ACE2, finding that [18F]F-MLN-4760 shows superior binding affinity and yield.
bioRxiv · Mar 20, 2024Pharmacology & Toxicology
J. Muehle, M. J. Rodrigues, J. Alenfelder, L. Juergenliemke, R. Guixa-Gonzalez, A. Bacchin, F. Andres, M. Hennig, H. Schihada, M. Cruesemann, G. Koenig, E. Kostenis, G. Schertler, X. Deupi
This study determines the crystal structures of FR and YM bound to G11, revealing they stabilize Gq/11 heterotrimers by reinforcing the G and Gβ interface.
bioRxiv · Oct 24, 2023 · PreprintBiochemistry
T. Gruhl, T. Weinert, M. Rodrigues, C. J. Milne, G. Ortolani, K. Nass, E. Nango, S. Sen, P. J. Johnson, C. Cirelli, A. Furrer, S. Mous, P. Skopintsev, D. James, F. Dworkowski, , Scher
This study uses ultrafast crystallography to reveal how photoactivated retinal initiates structural changes in rhodopsin, leading to GPCR activation and vision.
bioRxiv · Oct 14, 2022 · PreprintBiochemistry
J. Xu, G. Chen, H. Wang, S. Cao, J. Heng, X. Deupi, Y. Du, B. K. Kobilka
This paper describes a method using calcineurin fusion to improve cryo-EM structure determination of Family A GPCRs by enhancing particle alignment.
bioRxiv · Mar 27, 2022Biophysics
F. Cortesi, D. Escobar Camacho, M. Luehrmann, G. M. Sommer, F. Hidber, X. Deupi, K. Carleton, Z. Musilova
The paper identifies convergent evolution of green-sensitive LWS opsins in teleost fishes through genomic, structural, and expression analyses, showing repeated molecular and functional shifts toward green light sensitivity.
bioRxiv · May 8, 2021 · PreprintEvolutionary Biology
P. Isaikina, C.-J. Tsai, N. B. Dietz, F. Pamula, A. Grahl, K. N. Goldie, R. Guixa-Gonzalez, G. F. X. Schertler, O. Hartley, H. Stahlberg, T. Maier, X. Deupi, S. Grzesiek
The paper reports the cryo-EM structure of CCR5 bound to a chemokine agonist and Gi protein, revealing its activation mechanism.
bioRxiv · Nov 27, 2020Biophysics
I. Rodriguez-Espigares, M. Torrens-Fontanals, J. K. S. Tiemann, D. Aranda-Garcia, J. M. Ramirez-Anguita, T. M. Stepniewski, N. Worp, A. Varela-Rial, A. Morales-Pastor, B. Medel Lacruz, G. Pandy-Szekeres, E. Mayol, T. Giorgino, J. Carlsson, X. Deupi, , Wein
GPCRmd provides an online platform for visualizing and analyzing GPCR molecular dynamics simulations, demonstrating its utility through analyses of internal water networks and sodium ion interactions.
Nature Methods · Jul 13, 2020Peer-reviewedBiophysics
C.-J. Tsai, J. Marino, R. J. Adaixo, F. Pamula, J. Muehle, S. Maeda, T. Flock, N. M. Taylor, I. Mohammed, H. Matile, R. J. Dawson, X. Deupi, H. Stahlberg, G. F. Schertler
The paper presents a cryo-EM structure of the rhodopsin-Gαi-βγ complex, revealing the C-terminal tail of rhodopsin bound to the Gβ subunit and identifying common anchoring points across G protein-subtype interactions.
bioRxiv · Feb 12, 2019Biochemistry