Author

E. Lorentzen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. Basquin· 2 shared J. S. Andersen· 2 shared M. Loureiro-Lopez· 2 shared M. Taschner· 2 shared N. A. Petriman· 2 shared N. Boegholm· 2 shared R. B. Russell· 2 shared A. B. Bohn· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

J. Basquin

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

DLG1 functions upstream of SDCCAG3 and IFT20 to control ciliary targeting of polycystin-2

C. K. Rezi, M. Aslanyan, G. D. Diwan, T. Cheng, M. Chamlali, K. Junger, Z. Anvarian, e. lorentzen, K. B. Pauly, Y. Bahadori, E. F. Fernandes, F. Qian, S. Tosi, S. T. Christensen, S. F. Pedersen, , L. B. Pedersen

This study shows DLG1 regulates ciliary protein trafficking in kidney cells, with loss of DLG1 causing ciliary elongation and cysts, and a specific DLG1 variant linked to kidney disease.

bioRxiv · Nov 10, 2023Cell Biology

Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens

V. Ober, G. B. Githure, Y. Volpato Santos, S. Becker, G. Moya, J. Basquin, F. Schwede, E. Lorentzen, M. Boshart

This study identifies natural nucleosides as activators of PKA in trypanosomatid pathogens, showing they replace cAMP in allosteric regulation through specific binding to CNB domains.

bioRxiv · Oct 24, 2023Biochemistry

Analysis of cortical cell polarity by imaging flow cytometry

J. H. Jespersen, A. Harazin, A. B. Bohn, A. Christensen, E. Lorentzen, A. Lorentzen

This study develops an imaging flow cytometry-based method with AI support to efficiently screen factors affecting cortical cell polarity in melanoma cells.

bioRxiv · May 24, 2023Cell Biology

Biochemically validated structural model of the 15-subunit IFT-B complex

N. A. Petriman, M. Loureiro-Lopez, M. Taschner, N. K. Zacharia, M. M. Georgieva, N. Boegholm, A. Mourao, R. B. Russell, J. S. Andersen, E. Lorentzen

The paper presents a biochemically validated structural model of the 15-subunit IFT-B complex using AlphaFold and experimental validation techniques.

bioRxiv · Aug 20, 2022 · PreprintBiochemistry

The IFT81-IFT74 complex enhances GTP hydrolysis to inactivate RabL2 during early steps of intraflagellar transport

N. Boegholm, N. A. Petriman, M. Loureiro-Lopez, T. Kanie, P. K. Jackson, J. S. Andersen, E. Lorentzen

This study identifies the IFT81-IFT74 complex as a GTP hydrolysis enhancer for RabL2, crucial for inactivating RabL2 during early intraflagellar transport initiation.

bioRxiv · May 31, 2022 · PreprintBiochemistry

Nse5/6 inhibits the Smc5/6 ATPase to facilitate DNA substrate selection.

M. Taschner, J. Basquin, B. Steigenberger, I. Schaefer, Y.-M. Soh, C. Basquin, E. Lorentzen, M. Raeschle, R. A. Scheltema, S. Gruber

The paper shows Nse5/6 inhibits Smc5/6 ATPase activity, modulating DNA substrate selection in yeast.

bioRxiv · Feb 9, 2021Biochemistry