Author

Y.-M. Soh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cell Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:chromatin & epigenetic regulation· 4 Organism:bacteria (other)· 2 Organism:yeast· 2 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

S. Gruber· 6 shared H. Antar· 2 shared J. Basquin· 2 shared A. Anchimiuk· 1 shared A. Martinez-Sanchez· 1 shared B. Pradhan· 1 shared B. Steigenberger· 1 shared C. Basquin· 1 shared

Activity by Year

2019-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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6 shared papersBiochemistry

S. Gruber

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Direct Cryo-ET observation of platelet deformation induced by SARS-CoV-2 Spike protein

C. C. Kuhn, N. Basnet, S. Bodakuntla, P. Alvarez- Brecht, S. Nichols, A. Martinez-Sanchez, L. Agostini, Y.-M. Soh, J. Takagi, C. Biertumpfel, N. Mizuno

This study observes SARS-CoV-2 Spike protein-induced platelet deformation and activation using cryo-ET and live imaging, identifying integrin vβ3 as a binding target.

bioRxiv · Nov 22, 2022Cell Biology

ParS-independent recruitment of the bacterial chromosome-partitioning protein ParB

M. Tisma, M. Panoukidou, H. Antar, Y.-M. Soh, R. Barth, B. Pradhan, J. van der Torre, D. Michieletto, S. Gruber, C. Dekker

This study shows ParB can recruit itself to DNA independently of parS, enabling long-distance chromosome segregation in bacteria.

bioRxiv · Nov 2, 2021Biophysics

Relief of ParB autoinhibition by parS DNA catalysis and ParB recycling by CTP hydrolysis promote bacterial centromere assembly.

H. Antar, Y.-M. Soh, S. Zamuner, F. P. Bock, A. Anchimiuk, P. De Los Rios, S. Gruber

This study investigates how CTP hydrolysis and parS DNA catalysis influence ParB clamp closure and recycling, contributing to bacterial centromere assembly.

bioRxiv · May 5, 2021Biochemistry

Nse5/6 inhibits the Smc5/6 ATPase to facilitate DNA substrate selection.

M. Taschner, J. Basquin, B. Steigenberger, I. Schaefer, Y.-M. Soh, C. Basquin, E. Lorentzen, M. Raeschle, R. A. Scheltema, S. Gruber

The paper shows Nse5/6 inhibits Smc5/6 ATPase activity, modulating DNA substrate selection in yeast.

bioRxiv · Feb 9, 2021Biochemistry

Gradual opening of Smc arms in prokaryotic condensin

R. J. Vazquez Nunez, Y. Polyhach, Y.-M. Soh, G. Jeschke, S. Gruber

This study investigates the conformational changes in B. subtilis Smc-ScpAB, showing that arm separation depends on ATP and DNA, and that specific contacts regulate Smc function.

bioRxiv · Jan 21, 2021Biochemistry

A rod conformation of the Pyrococcus furiosus Rad50 coiled coil

Y.-M. Soh, J. Basquin, S. Gruber

The paper presents a crystal structure of an alternate conformation of the Pyrococcus furiosus Rad50 coiled coil, showing co-aligned coils instead of the previously reported anti-parallel arrangement.

bioRxiv · Jun 24, 2020Biochemistry

Phospho-regulation of the Shugoshin - Condensin interaction at the centromere in budding yeast

G. Metwaly, Y. Wu, K. Peplowska, J. Rohrl, Y.-M. Soh, F. Burmann, S. Gruber, Z. Storchova

The paper identifies a phosphorylation-regulated interaction between shugoshin and condensin at the centromere in budding yeast, essential for biorientation and chromosome segregation.

bioRxiv · Dec 16, 2019Cell Biology