F. Qian

DLG1 functions upstream of SDCCAG3 and IFT20 to control ciliary targeting of polycystin-2

This study shows DLG1 regulates ciliary protein trafficking in kidney cells, with loss of DLG1 causing ciliary elongation and cysts, and a specific DLG1 variant linked to kidney disease.

Intra-peritoneal transplantation for efficient and easy generation of experimental acute myeloid leukemia in mice

This study develops an intra-peritoneal injection method for generating a robust murine AML model using MLL-AF9-transduced bone marrow cells, showing it is efficient and reliable for serial transplantation.

AGL16 regulates genome-wide gene expression and flowering time with partial dependency on SOC1 in Arabidopsis

This study identifies AGL16's role in regulating gene expression and flowering time in Arabidopsis, showing partial dependency on SOC1 and involvement in water loss and seed dormancy.

Indoleamine 2,3-dioxygenase upregulates PD-1 expression on ovarian tumor infiltrating CD8+ T cells via kynurenine activation of the aryl hydrocarbon receptor

This study shows that IDO1 promotes PD-1 expression on CD8+ T cells in ovarian tumors through kynurenine-mediated AHR activation, suggesting therapeutic targeting of these pathways.

Allergen specific Treg upregulated by lung-stage schistosome infection alleviates allergic airway inflammation via inhibiting IgE secretion

This study shows that lung-stage schistosome infection reduces allergic airway inflammation by increasing allergen-specific Treg cells that inhibit IgE and Th2 cytokine production.

Kinetic fingerprints differentiate anti-Aβ therapies

This study uses kinetic analysis and binding measurements to compare four anti-Aβ antibodies, showing aducanumab uniquely reduces Aβ oligomer flux.

Trans-epithelial Fluid Pumping Performance of Renal Epithelial Cells and Mechanics of Cystic Expansion

This study uses a microfluidic platform to show renal epithelial cells generate hydraulic pressure gradients, with PKD cells showing reversed fluid flow and higher stall pressure.