Cell BiologybioRxiv
DLG1 functions upstream of SDCCAG3 and IFT20 to control ciliary targeting of polycystin-2
C. K. Rezi, M. Aslanyan, G. D. Diwan…·L. B. Pedersen
This study shows DLG1 regulates ciliary protein trafficking in kidney cells, with loss of DLG1 causing ciliary elongation and cysts, and a specific DLG1 variant linked to kidney disease.
DOI 10.1038/s44319-024-00170-1