BBSome-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue
K. Sieckmann, N. Winnerling, D. J. Silva Ribeiro, R. Kardinal, L. M. Steinheuer, G. Schermann, C. Klausen, N. Blank-Stein, J. Schulte-Schrepping, C. Osei-Sarpong, M. Becker, L. Bonaguro, M. Beyer, K. Thurley, H. May-Simera, , D. Wachten
This study shows that primary cilia dysfunction in Bbs8-/- mice reduces adipose stem cells and promotes fibrogenic progenitors via disrupted Hedgehog signaling, affecting adipogenesis and lipid uptake.
bioRxiv · Jan 25, 2024 · PreprintCell Biology