Author

E. McEvoy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 2 Approach:mechanistic / dynamical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

V. B. Shenoy· 2 shared X. Chen· 2 shared A. T. Weeraratna· 1 shared A. VERBRUGGEN· 1 shared E. Moeendarbary· 1 shared F. Spill· 1 shared G. E. Marino· 1 shared J. A. Panadero Perez· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersBiophysics

V. B. Shenoy

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A novel mechanobiological model of bone metastasis reveals that mechanical stimulation inhibits the pro-osteoclastogenic effects of breast cancer cells

V. Kumar, S. M. Naqvi, A. VERBRUGGEN, E. McEvoy, L. McNamara

This study develops in vitro and computational models to show mechanical stimulation inhibits tumor-induced osteolysis in bone metastasis.

bioRxiv · Sep 19, 2022 · PreprintBioengineering

Modeling the three-way feedback between cellular contractility, actin polymerization, and adhesion turnover resolves the contradictory effects of RhoA and Rac1 on endothelial junction dynamics

E. McEvoy, T. Sneh, E. Moeendarbary, G. E. Marino, X. Chen, J. Escribano, F. Spill, J. M. Garcia-Aznar, A. T. Weeraratna, T. M. Svitkina, R. D. Kamm, V. B. Shenoy

This study develops a chemo-mechanical model to explain how RhoA and Rac1 differentially affect endothelial junction dynamics through their roles in contractility, adhesion turnover, and actin polymerization.

bioRxiv · Mar 15, 2021 · PreprintBiophysics

Influence of multi-axial dynamic constraint on cell alignment and contractility in engineered tissues

N. H. Reynolds, E. McEvoy, J. A. Panadero Perez, R. J. Coleman, P. McGarry

This study examines how tissue constraints and cyclic loading affect cell alignment and contractility in engineered tissues, finding that uniaxial constraints lead to higher contractile stress than biaxial ones.

bioRxiv · Aug 12, 2020Cell Biology

Gap junctions amplify spatial variations in cell volume in proliferating solid tumors

E. McEvoy, Y. Han, M. Guo, V. B. Shenoy

This study uses a mechano-osmotic model and experiments to show gap junctions amplify spatial volume variations in multicellular spheroids due to proliferation-induced solid stress.

bioRxiv · Apr 15, 2020Biophysics

An Active Chemo-mechanical Model to Predict Adhesion and Microenvironmental Regulation of 3D Cell Shapes

X. Chen, V. t. Boekhorst, E. McEvoy, P. Friedl, V. Shenoy

This study develops a chemo-mechanical model to predict how adhesions and microenvironmental properties regulate 3D cell shapes, validated with experiments on HT1080 cells and literature data.

bioRxiv · Jan 7, 2020 · PreprintBiophysics