R. D. Kamm

The paper develops engineered microvascular networks with a KLF2 reporter to study flow effects on vascular structure and function, finding increased KLF2 expression correlates with larger vessel diameters and improved barrier function.

This paper develops a microfluidic model of human lymphatic microvasculature to study transport phenomena and immune interactions, showing its utility for disease research and drug screening.

The paper develops personalized breast cancer models to identify biomechanical factors affecting drug penetration and discovers potential therapeutic targets.

This paper develops a microfluidic model of human glioblastoma to study nanoparticle trafficking across the blood-brain barrier and evaluates their therapeutic efficacy.

This study develops a chemo-mechanical model to explain how RhoA and Rac1 differentially affect endothelial junction dynamics through their roles in contractility, adhesion turnover, and actin polymerization.

This study shows that flow-conditioning improves endothelial function and prevents vessel regression in engineered human capillaries.