B. Fu

Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis

This study uses spatiotemporal transcriptomics to analyze immune dynamics in E. multilocularis infected mouse liver, identifying key immune cell roles and shifts in immune strategy during infection.

NSP4 mutation T492I drives rapid evolution of SARS-CoV-2 toward Omicron

This study shows that the NSP4 T492I mutation increases SARS-CoV-2 mutation rates and accelerates the emergence of Omicron-like mutations.

Seminal root angle is associated with root system architecture in durum wheat

This study examines the relationship between seminal root angle and root system architecture in durum wheat, showing distinct RSA patterns in wide and narrow genotypes at later growth stages.

RASP: Optimal single fluorescent puncta detection in complex cellular backgrounds

RASP detects fluorescent puncta in complex cellular backgrounds with high precision and speed, outperforming existing methods by using image gradients to separate objects from noise.

Multi-modal microvascular cerebral blood flow velocity mapping with 14T single-vessel MRI and optical microscopy in the mouse brain

This study combines 14T single-vessel MRI and optical microscopy to map cerebral blood flow velocity in mouse brain microvessels, validating measurements across modalities.

How formate dehydrogenase-lacking acetogen Clostridium bovifaecis utilize formate as the sole carbon source for its acetogenic growth?

This study investigates how Clostridium bovifaecis, an FDH-lacking acetogen, uses formate as the sole carbon source for acetogenesis by converting it to acetate with a 2.0:1 to 2.6:1 molar ratio.

Unlocking the microblogging potential for science and medicine

The paper analyzes Twitter activity of 6,000 biomedical scientists, finding gender differences in tweeting behavior and engagement patterns.

Nucleocapsid 203 mutations enhance SARS-CoV-2 immune evasion

This study shows that the nucleocapsid 203 mutation, combined with spike L452R, enhances SARS-CoV-2 immune evasion and fitness, contributing to the dominance of variants like Delta and Omicron.

Unconventional secretion of unglycosylated ORF8 is critical for the cytokine storm during SARS-CoV-2 infection

This study identifies unconventional secretion of unglycosylated ORF8 as critical for inducing cytokine storms during SARS-CoV-2 infection by interacting with IL17RA on macrophages.

Nucleocapsid mutation R203K/G204R increases the infectivity, fitness and virulence of SARS-CoV-2

This study shows that the N protein mutations R203K/G204R increase SARS-CoV-2 infectivity, replication, and virulence, contributing to its spread and disease severity.

Elucidation of an anaerobic pathway for metabolism of L-carnitine-derived γ-butyrobetaine to trimethylamine in human gut bacteria

This paper identifies an anaerobic pathway in gut bacteria that converts γ-butyrobetaine to trimethylamine, showing it is a major contributor to TMA production from L-carnitine in the human gut.

Robust neutralization assay based on SARS-CoV-2 S-bearing vesicular stomatitis virus (VSV) pseudovirus and ACE2-overexpressed BHK21 cells

This paper develops a robust neutralization assay using SARS-CoV-2 S-bearing VSV pseudovirus and ACE2-overexpressed BHK21 cells to screen antibodies and quantify neutralizing titers.

Virus-free and live-cell visualizing SARS-CoV-2 cell entry for studies of neutralizing antibodies and compound inhibitors

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.

An ABA Synthesis Enzyme Allele OsNCED2 Promotes the Aerobic Adaption in Upland Rice

This study identifies an OsNCED2 allele that enhances aerobic adaptation in upland rice by improving root development and drought tolerance through increased ABA synthesis.

Aberrant pathogenic GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe pulmonary syndrome patients of a new coronavirus

This study identifies aberrant GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe 2019-nCoV patients, linking them to immune damage and mortality.

Mechanical stress compromises multicomponent efflux complexes in bacteria

The paper shows mechanical stress, specifically shear stress, disrupts the CusCBA efflux complex in E. coli, increasing metal toxicity susceptibility.

Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR/Cas9 screening

The paper functionally links gene fusions to cancer cell fitness using drug sensitivity and CRISPR-Cas9 data, identifying rare functional fusions and novel therapeutic targets.

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

The paper identifies how ATM counteracts toxic non-homologous end-joining at broken replication forks by showing that loss of NHEJ components or BRCA1-A complex confers resistance to DNA-damaging agents in ATM-deficient cells.

Natural Variation of OsLG3 Controls Drought Stress Tolerance in Rice by Inducing ROS Scavenging

This study identifies natural variation in OsLG3 that enhances drought stress tolerance in rice by improving ROS scavenging, offering a genetic resource for breeding drought-tolerant rice.