Author

J. E. Chambers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 4 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

S. J. Marciniak· 3 shared A. Agrawal· 1 shared A. Brown· 1 shared A. J. T. Everden· 1 shared A. S. Shun-Shion· 1 shared A. Vidal-Puig· 1 shared C. Crapart· 1 shared C. Garces· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

S. J. Marciniak

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A quantitative pipeline to assess secretion of human leptin coding variants reveals mechanisms underlying leptin deficiencies

H. J. M. Baird, A. S. Shun-Shion, E. Mendes De Oliveira, D. Stalder, J. Eden, J. E. Chambers, I. S. Farooqi, D. C. Gershlick, D. J. Fazakerley

This study develops a medium-throughput assay to assess leptin secretion and identifies mutations causing proteasomal degradation or reduced secretion.

bioRxiv · Mar 1, 2024Cell Biology

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes

J. Nixon-Abell, F. S. Ruggeri, S. Qamar, T. W. Herling, M. A. Czekalska, Y. Shen, G. Wang, C. King, M. S. Fernandopulle, T. Sneideris, J. L. Watson, V. V. Pillai, W. Meadows, J. Henderson, J. E. Chambers, , P. St George Hyslop

This study shows ANXA11 biomolecular condensates couple protein and lipid phase states on lysosomal membranes through interactions with ALG2 and CALC.

bioRxiv · Mar 22, 2023Cell Biology

Endoplasmic Reticulum morphological regulation by RTN4/NOGO modulates neuronal regeneration by slowing luminal transport

T. Konno, P. Parutto, D. M. D. Bailey, V. Davi, C. Crapart, M. A. Awadelkareem, C. Hockings, A. Brown, K. M. Xiang, A. Agrawal, J. E. Chambers, M. V. Werp, K. Koning, E. Metzakopian, L. Westrate, , E. Avezov

The paper shows RTN4/NOGO regulates ER morphology, which modulates luminal transport and Ca2+ delivery, affecting axonogenesis in neurons.

bioRxiv · May 10, 2021Cell Biology

Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in mice

V. Patel, G. Bidault, J. E. Chambers, S. Carobbio, A. J. T. Everden, C. Garces, L. E. Dalton, F. M. Gribble, A. Vidal-Puig, S. J. Marciniak

This study shows that mice lacking PPP1R15A gain less weight and have improved insulin sensitivity on a high-fat diet but not on standard diet.

bioRxiv · May 4, 2018Physiology

The integrated stress response regulates BMP signaling through effects on translation

E. Malzer, C. S. Dominicus, J. E. Chambers, S. Mookerjee, S. J. Marciniak

This study shows that the integrated stress response (ISR) regulates BMP signaling in Drosophila through effects on translation and the transcription factor crc.

bioRxiv · Feb 16, 2018Cell Biology