Author

E. Mittler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 5 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:host-pathogen & immune response· 6 Approach:experimental assay· 5 Organism:human· 3 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Assay:clinical cohort / trial· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

K. Chandran· 6 shared R. K. Jangra· 4 shared R. H. Bortz· 2 shared T. P. Alkutkar· 2 shared A. C. Wong· 1 shared A. Dernstedt· 1 shared A. Puhar· 1 shared A. Tuiskunen-Back· 1 shared

Activity by Year

2019-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersMicrobiology

K. Chandran

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A glycoprotein mutation that emerged during the 2013-2016 Ebola virus epidemic alters proteolysis and accelerates membrane fusion

J. M. Fels, R. H. Bortz, T. P. Alkutkar, E. Mittler, R. K. Jangra, J. S. Spence, K. Chandran

This paper investigates how the A82V mutation in the Ebola virus glycoprotein enhances infectivity by altering proteolysis and accelerating membrane fusion.

mBio · Feb 23, 2021Peer-reviewedMicrobiology

Genetic depletion studies define receptor usage by virulent hantaviruses in human endothelial cells

M. E. Dieterle, C. Sola-Riera, R. K. Jangra, C. Ye, S. M. Goodfellow, E. Mittler, E. Kasikci, S. B. Bradfute, J. Klingström, K. Chandran

This study uses CRISPR/Cas9 to knock out potential hantavirus receptors in human endothelial cells, finding that PCDH1 is critical for some hantaviruses while other receptors like integrins and DAF are not essential.

bioRxiv · Dec 30, 2020Microbiology

Direct intracellular visualization of Ebola virus-receptor interaction by in situ proximity ligation

E. Mittler, T. P. Alkutkar, R. K. Jangra, K. Chandran

This paper introduces an in situ proximity ligation assay to visualize Ebola virus glycoprotein (GPCL) interaction with the receptor NPC1 in infected cells, revealing insights into viral entry mechanisms and drug inhibition.

bioRxiv · May 5, 2020Microbiology

Phenotypic heterogeneity in particle size is a viral mechanism of persistence

T. Li, Z. Li, E. E. Deans, E. Mittler, M. Liu, K. Chandran, T. Ivanovic

This study shows that filamentous viral particles have a functional advantage over spherical ones in resisting neutralizing antibodies and fusion inhibitors.

bioRxiv · Apr 23, 2020 · PreprintMicrobiology

A virion-based assay for glycoprotein thermostability reveals key determinants of filovirus entry and its inhibition

R. H. Bortz, A. C. Wong, M. G. Grodus, H. Recht, M. C. Pulanco, G. Lasso, S. J. Anthony, E. Mittler, R. K. Jangra, K. Chandran

This paper introduces an ELISA-based assay to measure the thermostability of filovirus glycoproteins, revealing how proteolytic cleavage, acid pH, and small-molecule inhibitors affect GP stability and viral entry.

bioRxiv · Feb 25, 2020Microbiology

The generation of plasma cells and CD27-IgD- B cells during Hantavirus infection are associated with distinct pathological findings

P. F. Kerkman, A. Dernstedt, L. Tadala, E. Mittler, M. Dannborg, C. Sundling, K. T. Maleki, J. Tauriainen, A. Tuiskunen-Back, J. Wigren Bystrom, P. Ocaya, T. Thunberg, R. Jangra, G. Roman-Sosa, P. Guardado-Calvo, , M. Forsell

This study links plasma cell and CD27-IgD- B cell generation during Hantavirus infection to distinct pathological features in HFRS.

bioRxiv · Aug 2, 2019Immunology