P. Yan

New insights into functional divergence and adaptive evolution of uncultured bacteria in anammox community by complete genome-centric analysis

The paper uses long-read sequencing to obtain complete metagenome-assembled genomes of anammox bacteria, revealing functional divergence and adaptive evolution through horizontal gene transfer and mobile genetic elements.

Collagenesis Orchestrates Mechanoadaptive Homeostasis of Intervertebral Disc

The paper identifies a novel mechanoadaptive process in intervertebral discs through collagenesis, revealing TRPV4's role in collagen II synthesis and mechanical stress adaptation.

Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2

This study develops nanoPDLIM2, a PDLIM2-expressing nanoparticle, which enhances PD-1 blockade and chemotherapy efficacy in lung cancer by reactivating tumor immunity and reducing drug resistance.

Structural basis for auto-inhibition and activation of a short prokaryotic Argonaute associated TIR-APAZ defense system

The paper determines cryo-EM structures of SPARTA in different states to elucidate its auto-inhibition and activation mechanisms.

Chimeric Antigen Receptor Macrophages Target and Resorb Amyloid Plaques in a Mouse Model of Alzheimer's Disease

This paper demonstrates that CAR-Ms engineered to secrete M-CSF can target and reduce amyloid plaques in a mouse model of Alzheimer's disease.

RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension

This study shows RAB7 deficiency impairs endothelial function and causes pulmonary hypertension in mice, with potential for RAB7 activation as a therapeutic strategy.

How Aberrant N-Glycosylation Can Alter Protein Functionality and Ligand Binding: an Atomistic View

The paper investigates how N-glycosylation of GRP94 modulates its conformational dynamics and ligand binding, providing insights for designing inhibitors targeting disease-associated conformations.

Development of amidase-dependent pyrazinoic acid prodrugs with activity against pyrazinamide resistant Mycobacterium tuberculosis

This paper develops amidase-dependent pyrazinoic acid prodrugs that bypass PncA activation, showing efficacy against PZA-resistant Mtb.

Enhanced soil quality after forest conversion to vegetable cropland and tea plantation has contrasting effects on soil microbial structure and functions

This study examines how soil quality changes after forest conversion to vegetable cropland and tea plantations, showing contrasting effects on microbial community structure and functions.

A Pan-Cancer Census of Dominant Tumor Immune Archetypes

The paper identifies dominant immune system archetypes across 364 tumors from 12 cancer types using flow cytometry and transcriptomic data, linking them to tumor biology classifications.

Variations in soil nutrient dynamics and bacterial communities in long-term tea monoculture production systems

This study examines how long-term tea monoculture affects soil nutrient dynamics and bacterial communities across different stand ages.

Quantitative three-dimensional nondestructive imaging of whole anaerobic ammonium-oxidizing bacteria

This study uses synchrotron soft X-ray nano-computed tomography to quantitatively image the 3D ultrastructure of intact anammox bacteria and explores their shape adaptation to Fe2+.

SCENITH: A flow cytometry based method to functionally profile energy metabolism with single cell resolution

SCENITH functionally profiles energy metabolism at single-cell resolution using flow cytometry, revealing variable metabolic profiles in tumor myeloid cells not linked to lineage or activation phenotype.

Spectral and lifetime fluorescence unmixing via deep learning

This paper introduces UNMIX-ME, a deep learning method for fluorescence unmixing that combines spectral and temporal data to improve quantification of fluorescent species in biological samples.

Deep Learning Enhanced Hyperspectral Fluorescence Lifetime Imaging

This paper introduces a deep learning framework for fast hyperspectral fluorescence lifetime imaging, achieving rapid acquisition and processing without training data.

Unbiased Assessment of H-STS cells as high-fidelity models for gastro-enteropancreatic neuroendocrine tumor drug mechanism of action analysis

The paper assesses H-STS cells as models for drug mechanism analysis in gastro-enteropancreatic neuroendocrine tumors using molecular criteria rather than histological features.

Proteolytic program-dependent functions are impaired in INF2-mediated focal segmental glomerulosclerosis.

This study identifies a proteolytic cleavage mechanism in INF2 that affects its function in podocytes, leading to impaired localization and contributing to FSGS.

Ultra-fast fit-free analysis of complex fluorescence lifetime imaging via deep learning

This paper introduces FLI-Net, a deep learning model that enables ultra-fast, fit-free analysis of fluorescence lifetime imaging data across multiple spectral ranges and acquisition technologies.

Tethered Bichromophoric Fluorophore Quencher Voltage Sensitive Dyes

This paper develops tethered bichromophoric fluorophore quencher (TBFQ) dyes for improved voltage sensing, achieving higher sensitivity and faster response kinetics than existing fluorescent voltage sensors.