P. Martin

New groups of highly divergent proteins in families as old as cellular life with important biological functions in the ocean

The paper identifies new divergent protein groups in ancient gene families from marine metagenomes, highlighting environmental diversity and potential biological novelty.

Allergic inflammation triggers dyslipidemia via IgG signalling

This study shows that IgG-mediated allergic inflammation increases serum triglycerides and alters lipid metabolism in mice and humans.

Lack of p38 activation in T cells increases IL-35 production and protects against obesity by promoting thermogenesis

This study shows that inhibiting p38 in T cells increases IL-35 production, which enhances thermogenesis and protects against obesity.

Locus specific human endogenous retroviruses reveal new lymphoma subtypes

The paper identifies unique HERV signatures in B-cell lymphoma subtypes that can improve classification and diagnosis when combined with gene expression.

Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant

This study evaluates bivalent SARS-CoV-2 mRNA vaccines and finds they induce broader neutralizing antibodies and better protection against BA.5 Omicron compared to monovalent vaccines.

The addition of FAIMS Increases Targeted Proteomics Sensitivity from FFPE Tumor Biopsies

This paper demonstrates that combining FAIMS with PRM enhances targeted proteomics sensitivity in FFPE tumor biopsies, particularly for HER2, EGFR, cMET, and KRAS.

Tapping into non-English-language science for the conservation of global biodiversity

This study shows non-English-language science provides crucial evidence for global biodiversity conservation, expanding geographical and taxonomic coverage but often with less robust study designs.

Early cross-coronavirus reactive signatures of protective humoral immunity against COVID-19

The paper profiles early humoral immune responses in COVID-19 patients, finding that survivors show rapid SARS-CoV-2-specific immunity linked to pre-existing OC43 immunity, while non-survivors have delayed and blunted responses.

Dissolved organic matter from tropical peatlands impacts shelf sea light availability on coral reefs in the Singapore Strait, Southeast Asia

This study shows that dissolved organic matter from tropical peatlands reduces light availability in shelf seas, affecting coral reef ecosystems in the Singapore Strait.

Disentangling cause and consequence: Genetic dissection of the DANGEROUS MIX2 risk locus, and activation of the DM2h NLR in autoimmunity

The paper identifies DM2h as the gene responsible for autoimmunity in Arabidopsis thaliana and shows that EDS1-YFPNLS activates the DM2h NLR independently of its normal immune regulatory function.

A lipocalin mediates unidirectional haem biomineralization in malaria parasites

This study identifies PV5, a lipocalin-like protein, as critical for controlling haem crystallization into haemozoin in malaria parasites, with implications for drug development.

HSP90 facilitates oncogenic alterations of metabolism in B-cell lymphomas

This study shows HSP90 supports metabolic compartmentalization in B-cell lymphomas, and its inhibition reduces cancer metabolism.

Uropathogenic E. coli induces DNA damage in the bladder

The paper reports colibactin production in human UTIs and its genotoxic effects on bladder cells, linking it to potential bladder cancer risk.

Transmembrane Stem Cell Factor Protein Therapeutics EnhanceRevascularization in Ischemia without Mast Cell Activation

This study develops tmSCF-based therapeutics that enhance revascularization in ischemia without activating mast cells, using proteoliposomes and lipid nanodiscs as delivery systems.

Highly efficient multiplex editing: One-shot generation of 8x Nicotiana benthamiana and 12x Arabidopsis mutants

The paper develops a toolkit for high-efficiency multiplex genome editing in plants, generating 8x Nicotiana benthamiana and 12x Arabidopsis mutants in a single generation.

The environmental impacts of palm oil and its alternatives

This study compares the environmental impacts of five major vegetable oils, finding oil palm has the lowest carbon and biodiversity loss per tonne of oil but affects range-restricted species more than sunflower and rapeseed.

Species, causes, and outcomes of wildlife rehabilitation in New York State

This study analyzes wildlife rehabilitation data in New York State to quantify species, causes, and outcomes of rehabilitation cases over time.

Climate change and deforestation boost post-fire grass invasion of Amazonian forests

The paper models how climate change, deforestation, and fires increase the risk of post-fire grass invasion in the Amazon, predicting higher vulnerability in the south-eastern region.

KH-type splicing regulatory protein controls colorectal cancer cell growth and modulates the tumor microenvironment

This study investigates KHSRP's role in colorectal cancer, showing it promotes tumor growth and modulates the tumor microenvironment through mechanisms involving cell proliferation and angiogenesis.

Temporal dynamics of Bacteria, Archaea and protists in equatorial coastal waters

The paper examines microbial community dynamics in equatorial coastal waters of Singapore, finding distinct seasonal patterns in the Singapore Strait but not in the Johor Strait.

Live imaging the Foreign Body Response reveals how dampening inflammation reduces fibrosis

The paper uses live imaging in zebrafish to study the Foreign Body Response, showing that reducing inflammation decreases fibrosis and tissue scarring.

Active cargo positioning in antiparallel transport networks

The paper studies cargo positioning in antiparallel actin networks using colloidal beads and myosin motors, finding that beads accumulate at regions of neutral polarity with motor-dependent precision.

Stiffness and tension gradients of the hair cell’s tip-link complex in the mammalian cochlea

The paper investigates mechanical properties of hair cells in the rat cochlea, finding stiffness and tension gradients that correlate with tonotopy and contribute to frequency tuning.

Life Inside A Dinosaur Bone: A Thriving Microbiome

This study shows that Late Cretaceous dinosaur bones host a living microbiome, distinct from surrounding sediment, challenging assumptions about fossil preservation and original organic material.

Vasculature-associated adipose tissue macrophages dynamically adapt to inflammatory and metabolic challenges

The paper identifies vasculature-associated adipose tissue macrophages (VAMs) and shows how they adapt to metabolic and inflammatory challenges in epididymal white adipose tissue.