Author

P. Langella

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

C. Danne· 2 shared C. Galbert· 2 shared C. Oeuvray· 2 shared H. Sokol· 2 shared N. Rolhion· 2 shared T. Ledent· 2 shared A. Agus· 1 shared A. Lapiere· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

C. Danne

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Gene co-expression network analysis of the human gut commensal bacterium Faecalibacterium prausnitzii based on WGCNA in R-Shiny

S. Auger, V. Mournetas, H. Chiapello, V. Loux, P. Langella, J.-M. Chatel

This study uses WGCNA to analyze gene expression in F. prausnitzii, identifying co-expression modules linked to metabolic processes and stress response mechanisms.

bioRxiv · Jul 10, 2022Microbiology

Human CD4+/CD8α+ regulatory T cells induced by Faecalibacterium prausnitzii protect against intestinal inflammation

S. Touch, E. Godefroy, N. Rolhion, C. Danne, C. Oeuvray, M. Straube, C. Galbert, L. Brot, I. Alonso Salgueiro, S. Chadi, T. Ledent, J. M. Chatel, P. Langella, F. Jotereau, F. Altare, H. Sokol

The paper shows that human CD4+/CD8α+ regulatory T cells induced by Faecalibacterium prausnitzii reduce intestinal inflammation in a mouse model and correlate with disease activity in IBD patients.

bioRxiv · Mar 22, 2022Immunology

CARD9 in Neutrophils Protects from Colitis and Controls Mitochondrial Metabolism and Cell Survival

C. Danne, C. Michaudel, J. Skerniskyte, J. Planchais, A. Magniez, A. Agus, M.-L. Michel, B. Lamas, G. Da-Costa, M. Spatz, C. Oeuvray, C. Galbert, M. Poirier, Y. Wang, A. Lapiere, , H. Sokol

This study identifies CARD9's protective role in neutrophils against colitis by maintaining mitochondrial function and cell survival, revealing a mechanism for intestinal inflammation control.

bioRxiv · Jan 14, 2022Immunology

A toxic friend: Genotoxic and mutagenic activity of the probiotic strain Escherichia coli Nissle 1917

J.-P. Nougayrede, C. Chagneau, J.-P. Motta, N. Bossuet-Greif, M. Belloy, F. Taieb, J.-J. Gratadoux, M. Thomas, P. Langella, E. Oswald

This study shows that the probiotic Escherichia coli Nissle 1917 produces the genotoxin colibactin, which induces DNA damage and mutagenesis in vitro and in vivo.

bioRxiv · Mar 22, 2021Microbiology

Capsular polysaccharides cross-regulation modulates Bacteroides thetaiotaomicron biofilm formation

N. BECHON, J. MIHAJLOVIC, S. VENDRELL-FERNANDEZ, F. CHAIN, P. LANGELLA, C. BELOIN, J.-M. GHIGO

This study identifies capsular polysaccharide cross-regulation as a key determinant of Bacteroides thetaiotaomicron biofilm formation, showing that capsule 8 has intrinsic adhesive properties while other capsules inhibit biofilm formation.

bioRxiv · Mar 25, 2020Microbiology