B. Brown

12/15-Lipoxygenases mediate neuropathic-like pain hypersensitivity in female mice

This study shows that 12/15-Lipoxygenases contribute to neuropathic-like pain hypersensitivity in female mice, with inhibitors reversing pain symptoms.

A method for focused ultrasound (FUS) neuromodulation with simultaneous electroencephalogram recordings in awake, head-fixed mice with temporal lobe epilepsy

This study develops a method to apply focused ultrasound neuromodulation in awake, head-fixed mice with temporal lobe epilepsy and evaluates its effects on seizure-like events.

The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program

The paper analyzes tissue-resident regulatory T cells (Tregs) in non-lymphoid organs, showing they share phenotypes, transient residency, and TCR sequences, with tissue-agnostic re-entry capabilities.

A Genetic and Immunohistochemical Analysis of H. Pylori Phenotypes and p27 expression in Adenocarcinoma Patients in Jordan

This study analyzes H. pylori genotypes and p27 expression in Jordanian adenocarcinoma patients to explore their association with gastric cancer.

A replicon RNA vaccine induces durable protective immunity from SARS-CoV-2 in nonhuman primates after neutralizing antibodies have waned

This study shows a replicon RNA vaccine provides durable protection against SARS-CoV-2 in nonhuman primates even after neutralizing antibodies decline.

Development of an HIV reporter virus that identifies latently infected CD4+ T cells

This study develops an HIV reporter virus to identify latently infected CD4+ T cells and finds that over 50% of infected cells harbor silent proviruses.

Shift of lung macrophage composition is associated with COVID-19 disease severity and recovery

This study identifies shifts in lung macrophage composition linked to COVID-19 severity and recovery, suggesting therapeutic strategies targeting macrophage function.

Architecture of the cytoplasmic face of the nuclear pore

The paper establishes the near-atomic molecular architecture of the cytoplasmic face of the human nuclear pore complex using interdisciplinary methods.

Architecture of the linker-scaffold in the nuclear pore

The paper establishes the near-atomic molecular architecture and evolutionary conservation of the linker-scaffold in the human nuclear pore complex.

The Transcription Factor Xrp1 is Required for PERK-Mediated Antioxidant Gene Induction in Drosophila

The paper shows that Xrp1, not ATF4, mediates PERK-induced antioxidant gene expression in Drosophila through a conserved uORF mechanism.

Hematologic and systemic metabolic alterations due to Mediterranean type II G6PD deficiency in a novel murine model

This study creates a novel murine model of severe G6PD deficiency by introducing a human mutation, revealing metabolic alterations and hemolytic sequelae similar to humans.

A high affinity human monoclonal antibody against Pfs230 binds multiple parasite stages and blocks oocyst formation in mosquitoes

The paper identifies a high-affinity human monoclonal antibody against Pfs230 that blocks oocyst formation in mosquitoes by targeting gamete surfaces.

Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2

This study designs SARS-CoV-2 nanoparticle vaccines that induce strong neutralizing antibodies in mice, with higher titers and lower doses than existing trimer vaccines.

Effects of exclusive breastfeeding on infant gut microbiota: a meta-analysis across studies and populations

This study meta-analyzes seven studies to show that exclusive breastfeeding increases gut microbiota diversity and specific metabolic pathways while reducing others, with benefits persisting beyond six months.