S. Andrews

The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program

The paper analyzes tissue-resident regulatory T cells (Tregs) in non-lymphoid organs, showing they share phenotypes, transient residency, and TCR sequences, with tissue-agnostic re-entry capabilities.

Native size exclusion chromatography-based mass spectrometry (SEC-MS) identifies novel components of the Heat Shock Protein 90-dependent proteome

This study uses SEC-MS to analyze HSP90 inhibitor effects on protein complexes, identifying both known and novel components of the HSP90-dependent proteome.

Individual differences in members of Actinobacteria, Bacteroidetes, and Firmicutes is associated with resistance or vulnerability to addiction-like behaviors in heterogeneous stock rats

The paper identifies microbiome composition and metabolic pathways associated with resistance or vulnerability to addiction-like behaviors in rats using a large cohort and extended cocaine self-administration.

TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells

This study shows that TGFβ signalling maintains naive human pluripotency by regulating SMAD2/3 binding and gene expression, with distinct effects compared to primed hPSCs.

High-throughput, multiplex microfluidic test strip for the determination of antibiotic susceptibility in uropathogenic E. coli with smartphone detection

This paper evaluates a high-throughput microfluidic test strip for antibiotic susceptibility testing in uropathogenic E. coli, showing high agreement with standard methods.

IL-7R signalling activates widespread VH and DH gene usage to drive antibody diversity in bone marrow B cells

This study shows IL-7R signalling influences VH and DH gene usage in bone marrow B cells, shaping the Igh repertoire through epigenetic mechanisms.

Tuning TPO-R signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia

This study develops diabody ligands that modulate TPO-R signaling, showing partial agonists preserve HSCs and inhibit ET oncogenesis.

LipidFinder 2.0: advanced informatics pipeline for lipidomics discovery applications

LipidFinder 2.0 improves lipidomics analysis with new modules for artefact filtering, isotope deletion, and FDR assessment, showing better performance than existing tools.

Modelling the spatial-temporal distributions and associated determining factors of a keystone pelagic fish

The paper models the spatial-temporal distribution of capelin using Maxent, showing seasonal variations in occurrence probabilities and variable importance of oceanographic factors.

Plasmodium falciparum-specific IgM B cells dominate in children, expand with malaria and produce parasite inhibitory IgM

The paper identifies Pf-specific IgM B cells in children, showing they expand during malaria and produce inhibitory IgM antibodies.

Structure of HIV-2 Nef reveals unique features distinct from HIV-1 involved in immune regulation

This study reports the crystal structure of HIV-2 Nef, revealing unique features compared to HIV-1 that may contribute to immune regulation and viral pathogenesis.