Pharmacologic IRE1/XBP1s Activation Promotes Systemic Adaptive Remodeling in Obesity
A. Madhavan, B. P. Kok, J. M. Grandjean, V. Albert, A. Sukiasyan, B. Rius, E. Powers, A. Galmozzi, E. Saez, L. Wiseman
This study shows that pharmacologic activation of IRE1/XBP1s signaling in obese mice improves glucose metabolism, insulin action, and reduces hepatic steatosis and inflammation.
bioRxiv · Dec 3, 2020Physiology