A. Madhavan

PERK Signaling Promotes Mitochondrial Elongation By Remodeling Membrane Phosphatidic Acid

The paper shows PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid during ER stress.

Chrysomycin A inhibits the topoisomerase I of Mycobacterium tuberculosis.

This study identifies chrysomycin A as an inhibitor of topoisomerase I in Mycobacterium tuberculosis, showing bactericidal activity and synergy with existing anti-TB drugs.

Pharmacologic IRE1/XBP1s Activation Promotes Systemic Adaptive Remodeling in Obesity

This study shows that pharmacologic activation of IRE1/XBP1s signaling in obese mice improves glucose metabolism, insulin action, and reduces hepatic steatosis and inflammation.

Transcription repressor protein ZBTB25 interacts with HDAC1 in macrophages infected with Mycobacterium tuberculosis, and its inhibition leads to autophagy and killing of the intracellular pathogen

The paper shows that ZBTB25 interacts with HDAC1 in MTB-infected macrophages, and inhibiting this interaction promotes autophagy and kills the pathogen.

Acetylation of isoniazid - a novel mechanism of isoniazid resistance in Mycobacterium tuberculosis

This study identifies Rv2170 as an acetyltransferase that inactivates isoniazid by acetylation, providing a novel mechanism for isoniazid resistance in Mycobacterium tuberculosis.