Author

E. Saez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:metabolism & bioenergetics· 2 Organism:mouse· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

L. Wiseman· 2 shared V. Albert· 2 shared A. Galmozzi· 1 shared A. Madhavan· 1 shared A. N. Murphy· 1 shared A. S. Divakaruni· 1 shared A. Sukiasyan· 1 shared B. L. Taylor· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

L. Wiseman

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Covalent targeting as a common mechanism for inhibiting NLRP3 inflammasome assembly.

C. Stanton, J. Sun, K. Nutsch, J. D. Rosarda, T. Nguyen, C. Li-Ma, S. Kutseikin, E. Saez, J. R. Teijaro, L. Wiseman, M. J. Bollong

This study identifies covalent compounds that inhibit NLRP3 inflammasome assembly by targeting reactive cysteines, suggesting NLRP3 as an electrophile sensor for inflammatory signaling.

bioRxiv · Jun 1, 2023Biochemistry

Pharmacologic IRE1/XBP1s Activation Promotes Systemic Adaptive Remodeling in Obesity

A. Madhavan, B. P. Kok, J. M. Grandjean, V. Albert, A. Sukiasyan, B. Rius, E. Powers, A. Galmozzi, E. Saez, L. Wiseman

This study shows that pharmacologic activation of IRE1/XBP1s signaling in obese mice improves glucose metabolism, insulin action, and reduces hepatic steatosis and inflammation.

bioRxiv · Dec 3, 2020Physiology

Integrated in vivo quantitative proteomics and nutrient tracing reveals age-related metabolic rewiring of pancreatic β-cell function

M. Wortham, J. R. Benthuysen, M. Wallace, J. N. Savas, F. Mulas, A. S. Divakaruni, F. Liu, V. Albert, B. L. Taylor, Y. Sui, E. Saez, A. N. Murphy, J. R. Yates, C. M. Metallo, M. Sander

This study uses in vivo proteomics and nutrient tracing to show age-related metabolic changes in pancreatic β-cells improve glucose-stimulated insulin secretion.

bioRxiv · Oct 24, 2018Physiology