The structure of insulin granule core determines secretory capacity being reduced in type-2 diabetes
M. Barghouth, X. Jiang, M. Nagao, N. Chen, D. Yang, Y. Ye, C. Luan, M. Gomez, A. M. Blom, C. Wollheim, L. Eliasson, E. Renstrom, E. Zhang
The paper investigates the structure of insulin granule cores and shows that their size reduction in type-2 diabetes correlates with impaired insulin secretion.
bioRxiv · Feb 22, 2022 · PreprintPhysiology