N. Chen

COMPREHENSIVE GENETIC INVESTIGATION REVEALS HETEROGENEOUS PATHWAYS TO OBSTRUCTIVE SLEEP APNEA

This study identifies 14 genome-wide significant loci for obstructive sleep apnea, including three independent of BMI, and highlights genetic pathways involving obesity, neurological, and craniofacial factors.

Immunomodulatory Porous Regenerative Scaffolds for in situ Vascular Engineering

This study demonstrates that immunomodulatory porous scaffolds improve vascular graft healing by promoting endothelialization and transmural cellular infiltration compared to standard PTFE grafts.

Temperature-Dependent Fold-Switching Mechanism of the Circadian Clock Protein KaiB

This study investigates how temperature affects the fold-switching mechanism of KaiB, a circadian clock protein, showing that proline isomerization is a rate-limiting step.

Supervised and unsupervised deep learning-based approaches for studying DNA replication spatiotemporal dynamics

This study uses supervised and unsupervised deep learning to analyze DNA replication dynamics in mouse cells, identifying altered patterns in Rif1-deficient cells and extending to patient samples.

Pseudocobalamin production and use in marine Synechococcus cultures and communities

This study measures pseudocobalamin and methionine synthase in Synechococcus cultures and communities, showing consistent pseudocobalamin quotas in the Northwest Atlantic Ocean.

Granzyme B-based CAR T cells block metastasis by eliminating circulating tumor cells

This study develops GrB-CAR T cells targeting mHSP70 to eliminate CTCs and inhibit metastasis in solid tumors.

Glioma-associated fibroblasts promote glioblastoma resistance to temozolomide through CCL2-CCR2 paracrine signaling

This paper shows that glioma-associated fibroblasts enhance glioblastoma resistance to temozolomide by secreting CCL2, which activates the ERK1/2 pathway in cancer cells.

Impacts of increasing isolation and environmental variation on Florida Scrub-Jay demography

The paper uses a 34-year dataset to show that Florida Scrub-Jay populations remain stable despite isolation and inbreeding due to increased breeder survival.

Ecological niche contributes to the persistence of the Western x Glaucous-winged Gull hybrid zone

The paper examines the role of ecological factors in maintaining a stable hybrid zone between western and glaucous-winged gulls, finding evidence of niche divergence and supporting the bounded superiority model.

A novel "ceasefire" model to explain efficient seed transmission of Xanthomonas citri pv. fuscans to common bean.

The paper uses a multi-omic approach to study Xanthomonas citri pv. fuscans interaction with common bean seeds, revealing a dynamic molecular dialogue and proposing a 'ceasefire' model for seed-pathogen interaction.

Translocations spur population growth but exacerbate inbreeding in an imperiled species

This study examines the effects of mitigation translocations on Florida Scrub-Jays, showing population growth but increased inbreeding and genetic diversity loss due to reproductive skew.

SARS-CoV-2 spike protein induces the cytokine release syndrome by stimulating T cells to produce more IL-2

This study identifies that SARS-CoV-2 spike protein induces cytokine release syndrome by enhancing T cell production of IL-2, which drives inflammatory cytokine release through TLR4 and NF-κB activation.

Study on the preparation of bovine milk exosomes and the stability of lyophilized powder

This study prepares bovine milk exosomes and evaluates the stability of their lyophilized powder, showing it can be stored at room temperature for 3 months and 2-8°C for 15 months.

B Cells Promote T Cell Immunosenescence and Mammalian Aging Parameters

The paper identifies B cells as drivers of T cell immunosenescence and aging, showing that targeting B cells with CD20 antibodies can reverse age-related T cell dysfunction.

Genome-wide Perturbation Analysis Screening System for Exosomes-Related Genes Based on the CRISPR/Cas9 Platform

The paper develops a CRISPR-UMI-based screening system to study exosome biogenesis, transport, and uptake mechanisms on a genome-wide scale.

Co-occurrence of ST412 Klebsiella pneumoniae isolates with hypermucoviscous and no-mucoviscous phenotypes in a short-term hospitalized patient

This study identifies co-occurrence of hypermucoviscous and non-hypermucoviscous K. pneumoniae phenotypes in a clonal population, linked to specific mutations and metabolic gene dysregulation.

HDAC4-mediated deacetylation of GSDMD prevents pyroptosis by inhibiting GSDMD ubiquitination

This study identifies HDAC4-mediated deacetylation of GSDMD as a mechanism to inhibit pyroptosis by preventing GSDMD ubiquitination.

In vivo evolution of a Klebsiella pneumoniae capsule defect promotes complement-mediated opsono-phagocytosis and persistence during recurrent infection

The paper identifies a capsule defect in K. pneumoniae that enhances complement-mediated opsonophagocytosis and persistence during recurrent infections.

A plant virus causes symptoms through the deployment of a host-mimicking protein domain to attract the insect vector

This study identifies how the tomato yellow leaf curl virus uses a host-mimicking protein domain to disrupt plant processes and attract insect vectors, facilitating viral spread.

Enhancer Reprogramming in Melanoma Immune Checkpoint Therapy Resistance

The paper identifies enhancer-based biomarkers of resistance to anti-PD-1 therapy in melanoma and suggests enhancer blockade combined with ICB as a potential strategy to improve treatment responses.

Diverse Strategies Utilized by Coronaviruses to Evade Antiviral Responses and Suppress Pyroptosis

This study identifies how coronaviruses like PEDV and SARS-CoV-2 evade antiviral responses by manipulating caspase-1 and inhibiting IFN-I signaling through proteolytic activities.

The porcine cGAS-STING pathway exerts an unusual antiviral function independent of IFN and autophagy

This study shows porcine STING has antiviral activity independent of IFN and autophagy, and also triggers apoptosis to resist viral infections.

Multimodal Prediction of Breast Cancer Recurrence Assays and Risk of Recurrence

This paper develops a deep learning model that predicts breast cancer recurrence using digital histology and clinical factors, outperforming a clinical nomogram and identifying patients who may avoid genomic testing.

Predicting the antigenic evolution of SARS-COV-2 with deep learning

This paper predicts SARS-CoV-2 antigenic evolution using MLAEP, a deep learning model that identifies mutations associated with immune escape and validates them through experiments.

Hydrological dynamics drive the transition of antibiotic resistance genes between particle-attached and free-living lifestyles in a deep freshwater reservoir

This study examines how seasonal hydrological changes affect the transition of antibiotic resistance genes between particle-attached and free-living lifestyles in a deep freshwater reservoir.

Identification of a small chemical as a lysosomal calcium mobilizer and characterization of its ability to inhibit autophagy and viral infection

The paper identifies G42 as a lysosomal calcium mobilizer that inhibits autophagy and viral infections by alkalizing lysosomal pH and blocking autophagosome-lysosome fusion.

Wetting and complex remodeling of membranes by biomolecular condensates

This study investigates how protein condensates interact with membranes, leading to morphological changes and introduces a theoretical framework to describe these interactions.

Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation

LncRNA Malat1 represses Th17 effector program by maintaining a critical bivalent super-enhancer and promotes intestinal inflammation

This study shows that lncRNA Malat1 restricts Th17 cell IL-17A production by regulating a bivalent super-enhancer, thereby controlling intestinal inflammation resolution.

The structure of insulin granule core determines secretory capacity being reduced in type-2 diabetes

The paper investigates the structure of insulin granule cores and shows that their size reduction in type-2 diabetes correlates with impaired insulin secretion.