Author

C. Luan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. M. Blom· 1 shared B. Zhu· 1 shared C. Wollheim· 1 shared C. Yi· 1 shared D. Li· 1 shared D. Yang· 1 shared D. Zhang· 1 shared E. Renstrom· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperPhysiology

A. M. Blom

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Author profile →

2 papers

Recent·Most cited

Engineering precise adenine base editor with infinitesimal rates of bystander mutations and off-target editing

L. Chen, S. Zhang, N. Xue, M. Hong, X. Zhang, D. Zhang, J. Yang, S. Bai, Y. Huang, H. Meng, H. Wu, C. Luan, B. Zhu, G. Ru, M. Liu, , D. Li

This paper engineers a precise adenine base editor, ABE9, with reduced bystander mutations and off-target effects, enabling efficient and accurate A-to-G editing in mouse and rat embryos.

bioRxiv · Aug 12, 2022 · PreprintBioengineering

The structure of insulin granule core determines secretory capacity being reduced in type-2 diabetes

M. Barghouth, X. Jiang, M. Nagao, N. Chen, D. Yang, Y. Ye, C. Luan, M. Gomez, A. M. Blom, C. Wollheim, L. Eliasson, E. Renstrom, E. Zhang

The paper investigates the structure of insulin granule cores and shows that their size reduction in type-2 diabetes correlates with impaired insulin secretion.

bioRxiv · Feb 22, 2022 · PreprintPhysiology