Author

E. S. Chambers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Asfaw· 1 shared A. Gonzalez· 1 shared A. M. Richard· 1 shared A. N. Akbar· 1 shared A. Tang· 1 shared A. Warren· 1 shared B. B. Shih· 1 shared B. R. Paolella· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

A. Asfaw

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Age-linked lung pathology is reduced by immunotherapeutic targeting of isoDGR protein damage

P. Kalailingam, K.-H. Mohd-Kahliab, S. C. N. SoFong Cam Ngan, R. Iyappan, B. S. T. Lee, B. S. Bhargy Sharma, R. Machan, S. T. Bo, E. S. Chambers, V. A. Fajardo, R. E. K. Macpherson, J. Liu, P. Klentrou, E. L. Tsiani, K. L. Lim, , S. K. Sze

This study identifies isoDGR-damaged proteins as contributors to age-related lung pathology and shows that anti-isoDGR antibodies reduce lung damage in mice.

bioRxiv · Aug 11, 2023 · PreprintPathology

Phosphate dysregulation via the XPR1:KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer

D. P. Bondeson, B. R. Paolella, A. Asfaw, M. Rothberg, T. Skipper, C. Langan, A. Gonzalez, L. Surface, K. Ito, M. Kazachkova, W. N. Colgan, A. Warren, J. Dempster, J. M. Krill-Burger, M. Ericcson, , T. R. Golub

The paper identifies XPR1 and KIDINS220 as therapeutic targets in ovarian cancer by showing their role in phosphate dysregulation leading to cell death.

bioRxiv · Oct 16, 2020Cancer Biology

Monocyte-derived Prostaglandin E2 inhibits antigen-specific cutaneous immunity during ageing

E. S. Chambers, M. Vukmanovic-Stejic, B. B. Shih, H. Trahir, P. Subramanian, O. P. Devine, J. Glanville, D. Gilroy, M. Rustin, T. C. Freeman, N. A. Mabbott, A. N. Akbar

This study shows that inflammation from tissue injury in older adults reduces cutaneous immunity to VZV by recruiting monocytes that produce PGE2, which can be reversed with a p38-MAPK inhibitor.

bioRxiv · Apr 2, 2020Immunology