Author

K. L. Lim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. M. Richard· 2 shared C. P. Chen· 2 shared E. L. Tsiani· 2 shared I. H. Su· 2 shared K.-H. Mohd-Kahliab· 2 shared P. Kalailingam· 2 shared R. E. K. Macpherson· 2 shared R. Iyappan· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPathology

A. M. Richard

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Age-linked lung pathology is reduced by immunotherapeutic targeting of isoDGR protein damage

P. Kalailingam, K.-H. Mohd-Kahliab, S. C. N. SoFong Cam Ngan, R. Iyappan, B. S. T. Lee, B. S. Bhargy Sharma, R. Machan, S. T. Bo, E. S. Chambers, V. A. Fajardo, R. E. K. Macpherson, J. Liu, P. Klentrou, E. L. Tsiani, K. L. Lim, , S. K. Sze

This study identifies isoDGR-damaged proteins as contributors to age-related lung pathology and shows that anti-isoDGR antibodies reduce lung damage in mice.

bioRxiv · Aug 11, 2023 · PreprintPathology

Antibody targeting of aging damaged isoDGR-protein doubles lifespan in a mouse model of chronic inflammation

P. Kalailingam, K.-H. Mohd-Kahliab, S. C. Ngan, R. Iyappan, E. Melekh, T. Lu, G. W. Zien, B. Sharma, T. Guo, A. J. MacNeil, R. E. K. Macpherson, E. L. Tsiani, D. D. O'Leary, K. L. Lim, I. H. Su, , S. K. Sze

This paper shows that targeting aging-damaged isoDGR-proteins with antibodies extends lifespan in a mouse model of chronic inflammation.

bioRxiv · Mar 11, 2023 · PreprintBiochemistry

mTOR S-nitrosylation inhibits autophagy and lysosomal proteolysis

B. W. Q. Tan, S. Tan, B. W. L. Tan, S. Navakkode, C. Y. Ng, S. Yuan, M. C. Liang, C. Liu, S. Yin, C. Chai, K. C. M. Chew, Y. K. Tai, S. Sreedharan, Y. Lam, P. Liao, , T. W. Soong

This study identifies mTOR S-nitrosylation as a kinase-independent mechanism that suppresses autophagy and lysosomal proteolysis, with implications for Alzheimer's disease.

bioRxiv · Sep 11, 2020 · PreprintCell Biology