Author

E. Sanchez-Lopez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. M. A. de Graaf· 1 shared A. M. Otte· 1 shared A. Petersen· 1 shared A. Y. Peleg· 1 shared B. P. A. M. Heijs· 1 shared B. P. Howden· 1 shared C. Henriksen· 1 shared C. J. Halkes· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperBioengineering

A. M. A. de Graaf

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3 papers

Recent·Most cited

Advancing multi-day ex vivo kidney perfusion using spatially resolved metabolomics

M. J. A. de Haan, F. M. R. Witjas, A. M. A. de Graaf, M. E. Jacobs, E. Sanchez-Lopez, S. Kostidis, M. A. Giera, M. Maanaoui, T. Hubert, J. Kerr-Conte, F. Pattou, D. K. de Vries, J. Kers, I. P. J. Alwayn, C. van Kooten, , T. J. Rabelink

This study demonstrates that sub normothermic perfusion can preserve human kidneys metabolically for up to 8 days, maintaining metabolic activity and functional parameters for at least 4 days.

bioRxiv · May 10, 2023 · PreprintBioengineering

Novel determinant of antibiotic resistance: a clinically selected Staphylococcus aureus clpP mutant survives daptomycin treatment by reducing binding of the antibiotic and adapting a rod-shaped morphology

L. Xu, C. Henriksen, V. H. Mebus, R. Guerillot, A. Petersen, N. Jacques, J.-H. Jiang, R. Derks, E. Sanchez-Lopez, M. Giera, K. Leeten, T. P. Stinear, C. Oury, B. P. Howden, A. Y. Peleg, D. Frees

The paper identifies a clpP SNP mutation in MRSA that reduces daptomycin binding and enables survival through rod-shaped morphology, contributing to antibiotic resistance.

bioRxiv · Mar 6, 2023 · PreprintMicrobiology

Single cell guided deconvolution of bulk transcriptomics recapitulates differentiation stages of acute myeloid leukemia and predicts drug response

E. O. Karakaslar, J. F. Severens, E. Sanchez-Lopez, P. A. van Veelen, M. Zlei, J. J. van Dongen, A. M. Otte, C. J. Halkes, P. van Balen, H. Veelken, M. J. Reinders, M. Griffioen, E. B. van den Akker

This study uses single-cell data to deconvolute bulk RNA-seq samples of AML, showing that differentiation stages can be reconstructed and used to predict drug responses like Venetoclax resistance.

bioRxiv · Dec 9, 2022 · PreprintCancer Biology