The Spx stress regulator confers high-level β-lactam resistance and decreases susceptibility to last-line antibiotics in methicillin resistant Staphylococcus aureus
T. K. Nielsen, I. B. Petersen, L. Xu, M. D. Barbuti, V. H. Mebus, A. Justh, A. A. Alqarzaee, N. Jacques, C. Oury, V. C. Thomas, M. Kjos, C. Henriksen, D. Frees
This study identifies Spx as a stress regulator that enhances β-lactam resistance and reduces susceptibility to last-line antibiotics in MRSA through a redox-independent mechanism.
bioRxiv · Mar 1, 2024 · PreprintMicrobiology