Author

M. Griffioen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

A. A. de Waard· 2 shared M. H. M. Heemskerk· 2 shared M. L. M. Jongsma· 2 shared P. A. van Veelen· 2 shared R. M. Spaapen· 2 shared S. Bliss· 2 shared T. Verkerk· 2 shared A. H. de Ru· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersImmunology

A. A. de Waard

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Author profile →

3 papers

Recent·Most cited

Single cell guided deconvolution of bulk transcriptomics recapitulates differentiation stages of acute myeloid leukemia and predicts drug response

E. O. Karakaslar, J. F. Severens, E. Sanchez-Lopez, P. A. van Veelen, M. Zlei, J. J. van Dongen, A. M. Otte, C. J. Halkes, P. van Balen, H. Veelken, M. J. Reinders, M. Griffioen, E. B. van den Akker

This study uses single-cell data to deconvolute bulk RNA-seq samples of AML, showing that differentiation stages can be reconstructed and used to predict drug responses like Venetoclax resistance.

bioRxiv · Dec 9, 2022 · PreprintCancer Biology

The SPPL3-defined glycosphingolipid repertoire regulates immune responses by improving HLA class I access

M. L. M. Jongsma, M. Raaben, A. A. de Waard, T. Zhang, B. Cabukusta, R. Platzer, V. A. Blomen, A. Xagara, T. Verkerk, S. Bliss, L. Janssen, E. Stickel, S. Holst, R. Plomp, A. Mulder, , R. M. Spaapen

The paper identifies a glycosphingolipid (GSL) signature that inhibits HLA-I antigen presentation and shows its reversal by clinically approved drugs.

bioRxiv · Sep 26, 2020Immunology

Healthy cells functionally present TAP-independent SSR1 peptides: implications for selection of clinically relevant antigens

A. A. de Waard, T. Verkerk, K. Hoefakker, D. M. van der Steen, M. L. M. Jongsma, S. Bliss, A. H. de Ru, P. A. van Veelen, M. Griffioen, M. H. M. Heemskerk, R. M. Spaapen

The paper identifies TAP-independent antigen presentation in healthy cells using a T cell clone and highlights the need for comprehensive testing of healthy cell types to safely target antigens for immunotherapy.

bioRxiv · Jun 11, 2020Immunology