Pharmacology & ToxicologybioRxivPreprint
Procognitive and neurotrophic benefits of α5-GABA-A receptor positive allosteric modulation in a beta-amyloid deposition model of Alzheimer's disease pathology
A. M. Bernardo, M. Marcotte, K. Wong…·T. D. Prevot
This study shows that GL-II-73, a 5-GABAAR positive allosteric modulator, improves cognitive function and neuronal structure in Alzheimer's disease models despite beta-amyloid accumulation.
DOI 10.1101/2022.09.30.510361