T cell cholesterol transport is a metabolic checkpoint that links intestinal immune responses to dietary lipid absorption
Y. Gao, J. P. Kennelly, X. Xiao, E. Whang, A. Ferrari, A. H. Bedard, J. J. Mack, A. H. Nguyen, T. Weston, L. F. Uchiyama, M. S. Lee, S. Young, S. J. Bensinger, P. Tontonoz
This study identifies Aster-A as a cholesterol transporter in T cells that regulates immune signaling and metabolic responses by controlling membrane cholesterol levels.
bioRxiv · Mar 8, 2024Physiology