L. Cui

YAP/TAZ enhance P-body formation to promote tumorigenesis

This study shows YAP/TAZ promote P-body formation in cancer cells, enhancing tumorigenesis, and suggests targeting P-bodies or PNRC1 could be therapeutic.

Association study of Plasmodium falciparum Acetyl-CoA Synthetase Mutations S868G and V949I with antimalarial drugs

This study investigates the association of PfACAS mutations S868G and V949I with antimalarial drug resistance using whole-genome sequencing and CRISPR/Cas9-engineered parasites.

Acetyl-CoA Synthetase Mutations S868G and V949I Do Not Confer Resistance to Antimalarial Drugs in vitro in Plasmodium falciparum.

This study investigates whether mutations in PfACAS confer antimalarial drug resistance by engineering parasite lines with these mutations and testing their drug susceptibility in vitro.

A Fluorogenic Green Merocyanine-Based Probe to Detect Heparanase-1 Activity

This paper designs and synthesizes a fluorogenic green probe to detect HPSE-1 activity, showing a 278-fold fluorescence turn-on response in the presence of recombinant human HPSE-1.

Stable isotopes and nanoSIMS single-cell imaging reveals soil plastisphere colonizers able to assimilate sulfamethoxazole

This study uses stable isotopes and nanoSIMS to show soil bacteria on plastics can assimilate sulfamethoxazole, revealing their role in soil ecosystems.

Defining the Cell Surface Cysteinome using Two-step Enrichment Proteomics

The paper introduces a two-stage enrichment method called Cys-Surf to profile the cell surface cysteinome, identifying 821 ligandable cysteines and redox-sensitive residues with functional implications.

Aster-dependent non-vesicular transport facilitates dietary cholesterol uptake

The paper identifies the Aster pathway as critical for dietary cholesterol uptake and shows it can be targeted with a small molecule inhibitor.

Genetic basis of expression and splicing underlying spike architecture in wheat (Triticum aestivum L.)

This study identifies eQTLs and sQTLs associated with spike architecture in wheat, revealing genetic factors that regulate gene expression and splicing related to yield traits.

Discovery and Engineering of the L-Threonine Aldolase from Neptunomonas Marine for Efficient Synthesis of β-Hydroxy-α-Amino Acids via C-C Formation

This paper discovers and engineers an L-threonine aldolase from Neptunomonas marine to efficiently synthesize β-hydroxy-α-amino acids with high diastereoselectivity.

Viruses encode tRNA and anti-retron to evade bacterial immunity

This study identifies two viral strategies to evade bacterial retrons: supplying tRNATyr to counteract retron 78 and using Rad to degrade retron noncoding RNA precursors.

Within-patient evolution of plasmid-mediated antimicrobial resistance

This study tracks the evolution of plasmid-mediated antimicrobial resistance in hospitalized patients, revealing trade-offs between resistance levels and bacterial fitness.

Trophoblast and blood vessel organoid cultures recapitulate the role of WNT2B in promoting intravillous vascularization in human intrauterine and ectopic pregnancy

The paper uses organoid models to show that WNT2B promotes vascularization in pregnancies, linking trophoblast function to vascular development in both intrauterine and ectopic pregnancies.

Global Spatial Transcriptome of Macaque Brain at Single-Cell Resolution

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

Novel Murine models of Mania and Depression

This paper develops a novel murine model of mania through environmental stressors and validates it against depression models and controls.

Molecular basis of broad neutralization against SARS-CoV-2 variants including Omicron by a human antibody

A human antibody, VacW-209, broadly neutralizes SARS-CoV-2 variants including Omicron by targeting a conserved epitope, highlighting the importance of such antibodies in pandemic control.

Lack of authentic atrial fibrillation in commonly used murine atrial fibrillation models

This paper evaluates four commonly used murine models of atrial fibrillation and finds they do not exhibit authentic AF characteristics, such as micro-reentrant circuits or typical ECG features.

V367F mutation in SARS-CoV-2 spike RBD emerging during the early transmission phase enhances viral infectivity through increased human ACE2 receptor binding affinity

Transcriptome and metabolome analyses reveal pathways associated with fruit color in plum (Prunus salicina Lindl.)

The paper analyzes transcriptome and metabolome data from plum fruits at different developmental stages to identify pathways and genes associated with fruit color changes.

Genome-wide identification and characterization of DNA/RNA differences associated with Fusarium graminearum infection in wheat

This study identifies 187 DNA/RNA differences in 36 wheat genes associated with Fusarium head blight, showing their role in regulating FHB response through structural changes and miRNA interactions.

A self-immolative linker for heparanase activatable probe

This paper introduces a self-immolative linker that restores activity to an inactive heparanase probe, enabling facile development of activatable imaging probes.

A Versatile Linker for Probes Targeting Hydrolases via In Situ labeling

This study develops a versatile linker chemistry for in situ labeling of hydrolase-targeting probes using quinone methide species, showing improved labeling efficiency in living cells.

Endogenous RNA editing of a nuclear gene BOSS triggers flowering in tomato

The paper identifies RNA editing of the BOSS gene in tomato that regulates flowering by producing functionally distinct transcripts.

Amino acid-derived quorum sensing molecule alanine on the GIT tolerance of the lactobacillus strains in the co-cultured fermentation model

This study investigates how L-alanine, an amino acid-derived quorum sensing molecule, enhances the gastrointestinal tolerance of Lactobacillus acidophilus in a co-culture fermentation model.

Homogeneous environmental selection overturns distance-decay relationship of soil prokaryotic community

The paper shows that environmental selection overrides the distance-decay pattern in soil prokaryotic communities across biomes, revealing a U-shape pattern due to homogeneous environmental factors.

A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion and virulence in the malaria parasite Plasmodium falciparum

This study identifies a unique GCN5 histone acetyltransferase complex in Plasmodium falciparum that regulates erythrocyte invasion and virulence by modulating chromatin states and gene expression.

Outer membrane lipoprotein DolP interacts with the BAM complex and promotes fitness during envelope stress response

The paper identifies DolP as an interactor of the BAM complex that enhances bacterial fitness during envelope stress by counteracting excessive BAM accumulation.

Tuning TPO-R signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia

This study develops diabody ligands that modulate TPO-R signaling, showing partial agonists preserve HSCs and inhibit ET oncogenesis.

Telmisartan potentiates insulin secretion via ion channels, independent of the AT1 receptor and PPARγ

This study shows telmisartan enhances insulin secretion via ion channels, independent of AT1 receptor and PPARγ, in rat islets and diabetic mice.

A Human Multi-Lineage Hepatic Organoid Model for Liver Fibrosis

This study develops a human hepatic organoid model of ARPKD liver fibrosis, showing that the ARPKD mutation leads to fibrosis through TGFβ and PDGFRB pathways.

CD47 prevents the elimination of diseased fibroblasts in scleroderma

This study shows that CD47 protects scleroderma fibroblasts from immune elimination and that blocking CD47 with IL6 inhibition can reverse fibrosis in mice.