Author

P. Tontonoz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Organism:mouse· 4 Research Focus:differential expression· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell-cell communication· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

J. J. Mack· 2 shared J. P. Kennelly· 2 shared L. Cui· 2 shared X. Xiao· 2 shared A. Ferrari· 1 shared A. H. Bedard· 1 shared A. J. Lusis· 1 shared A. Nguyen· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersPhysiology

J. J. Mack

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6 papers

Recent·Most cited

Defining the Cell Surface Cysteinome using Two-step Enrichment Proteomics

T. Yan, L. Boatner, L. Cui, P. Tontonoz, K. Backus

The paper introduces a two-stage enrichment method called Cys-Surf to profile the cell surface cysteinome, identifying 821 ligandable cysteines and redox-sensitive residues with functional implications.

bioRxiv · Oct 17, 2023Biochemistry

Aster-dependent non-vesicular transport facilitates dietary cholesterol uptake

A. Ferrari, E. Whang, X. Xiao, J. P. Kennelly, B. Romartinez- Alonso, J. J. Mack, T. Weston, K. Chen, Y. Kim, M. Tol, L. Bideyan, A. Nguyen, Y. Gao, L. Cui, A. H. Bedard, , P. Tontonoz

The paper identifies the Aster pathway as critical for dietary cholesterol uptake and shows it can be targeted with a small molecule inhibitor.

bioRxiv · Jul 7, 2023 · PreprintPhysiology

Polarized Mechanosensitive Signaling Domains Protect Arterial Endothelial Cells Against Inflammation

S.-G. Hong, J. W. Ashby, J. P. Kennelly, M. Wu, E. Chattopadhyay, R. Foreman, P. Tontonoz, P. Turowski, M. Gallagher-Jones, J. J. Mack

The paper shows that polarized mechanosensitive domains in endothelial cells mediate anti-inflammatory signaling under high shear stress.

bioRxiv · May 26, 2023 · PreprintCell Biology

A cancer cell-intrinsic GOT2-PPARδ axis suppresses antitumor immunity

H. Sanford-Crane, J. Abrego, C. Oon, X. Xiao, S. Nagarajan, S. Bhattacharyya, P. Tontonoz, M. H. Sherman

This study identifies a cancer cell-intrinsic GOT2-PPARδ axis that suppresses antitumor immunity by restricting T cells and promoting immune-suppressive myeloid cells in PDAC.

bioRxiv · Dec 25, 2020 · PreprintCancer Biology

The Lands cycle modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle

P. J. Ferrara, X. Rong, J. A. Maschek, A. R. Verkerke, P. Siripoksup, H. Song, K. C. Krishnan, J. M. Johnson, J. Turk, J. A. Houmard, A. J. Lusis, J. E. Cox, S. R. Shaikh, P. Tontonoz, K. Funai

The study identifies LPCAT3 as a key regulator of plasma membrane lipid organization and insulin sensitivity in skeletal muscle, showing its role in modulating lipid metabolism and insulin action.

bioRxiv · Dec 23, 2019 · PreprintPhysiology

Single Cell Analysis Reveals Immune Cell-Adipocyte Crosstalk Regulating the Transcription of Thermogenic Adipocytes

P. Rajbhandari, D. Arneson, A.-C. Feng, I. S. Ahn, G. Diamante, N. Zaghari, B. Thomas, L. Vergnes, S. Lee, K. Reue, S. Smale, X. Yang, P. Tontonoz

The paper identifies immune cell-adipocyte communication regulating thermogenic adipocyte transcription through single-cell analysis in mice.

bioRxiv · Jun 13, 2019Cell Biology