VRK1 is a Paralog Synthetic Lethal Target in VRK2-methylated Glioblastoma
J. A. Shields, S. R. Meier, M. Bandi, M. Dam Ferdinez, J. L. Engel, E. E. Mulkearns-Hubert, N. Hajdari, K. Mitchell, W. Zhang, S.-c. Zhao, M. Zhang, R. Tjin Tham Sjin, E. Wilker, J. Lathia, J. Andersen, , N. Emmanuel
This study identifies VRK1 as a synthetic lethal target in VRK2-methylated glioblastoma by showing that VRK1 inhibition leads to tumor growth inhibition in xenograft models.
bioRxiv · Dec 30, 2021 · PreprintCancer Biology