Cell BiologybioRxiv
Nucleation of the destruction complex on the centrosome accelerates degradation of β-catenin and regulates Wnt signal transmission
R. S. Lach, C. Qiu, E. Z. Kajbaf…·M. Z. Wilson
The paper shows that centrosome-nucleated biomolecular condensates of the Destruction Complex enhance β-catenin degradation and regulate Wnt signaling in human embryonic stem cells.
DOI 10.1073/pnas.2204688119