C. Qiu

A higher order PUF complex is central to regulation of C. elegans germline stem cells

The paper identifies a ternary PUF complex in C. elegans that regulates germline stem cells by repressing and activating gld-1 mRNA through adjacent FBEs.

Structural insights into sphingosine 1-phosphate receptor 4 activation

The paper determines the cryo-EM structure of activated S1PR4, revealing mechanisms of ligand recognition and Gi coupling to aid in developing safer S1PR4 agonists.

Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome.

This study combines bulk RNA-Seq datasets to create a transcriptomic landscape of meningiomas, identifies subtypes with distinct biology and prognosis, and provides an interactive tool for outcome prediction.

Role of Staphylococcus aureus Buoyant Density in the Development of Biofilm Associated Antibiotic Resistance

This study shows that Staphylococcus aureus cells with lower buoyant density resist antibiotics more and form biofilms at air-liquid interfaces, while higher buoyant density cells are more antibiotic-sensitive and form biofilms on liquid-solid interfaces.

Structural basis of transcription: RNA Polymerase II substrate binding and metal coordination at 3.0 A using a free-electron laser

This paper presents the structure of ATP-bound RNA Polymerase II at 3.0 Å resolution using a free-electron laser, revealing new insights into substrate binding and metal coordination in the active site.

Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2

This study reports cryo-EM structures of HCAR2-Gi1 complexes with agonists, revealing ligand recognition, selectivity, and activation mechanisms for drug design.

Multi-omics of the gut microbial ecosystem in the immunotherapy resistance in microsatellite instability-high gastrointestinal cancer patients

The paper uses multi-omics data to identify gut microbiome and metabolite markers of immunotherapy resistance in MSI-H/dMMR gastrointestinal cancer patients and develops a predictive model with 0.83 accuracy.

Characterization of RNA Polymerase II Trigger Loop Mutations using Molecular Dynamics Simulations and Machine Learning

This study uses molecular dynamics and machine learning to analyze RNA Polymerase II trigger loop mutations, finding that ML can predict phenotypes from sequences and MD data reveals structural changes linked to mutation effects.

Characterization of Hydrophobic Interactions of SARS-CoV-2 and MERS-CoV Spike Protein Fusion Peptides Using Single Molecule Force Measurements

This study uses single molecule force measurements to quantify hydrophobic interactions in SARS-CoV-2 and MERS-CoV FP1 sequences, revealing that a single residue difference significantly affects interaction strength.

Omicron booster in ancestral strain vaccinated mice augments protective immunities against both the Delta and Omicron variants

This study shows that an Omicron-matched DNA vaccine booster enhances cross-reactive immunity against Delta and Omicron variants in mice compared to an ancestral strain booster.

Nucleation of the destruction complex on the centrosome accelerates degradation of β-catenin and regulates Wnt signal transmission

The paper shows that centrosome-nucleated biomolecular condensates of the Destruction Complex enhance β-catenin degradation and regulate Wnt signaling in human embryonic stem cells.

CD8+ T cell epitope variations suggest a potential antigen presentation deficiency for spike protein of SARS-CoV-2

The paper identifies HLA-A2 restricted T cell epitopes in SARS-CoV-2 spike protein and finds that variations in these epitopes may reduce T cell activation and contribute to immune escape.

A genome wide copper-sensitized screen identifies novel regulators of mitochondrial cytochrome c oxidase activity

Human IgG neutralizing monoclonal antibodies block SARS-CoV-2 infection

This study identifies potent human neutralizing antibodies against SARS-CoV-2 from convalescent patients, with some showing high efficacy in blocking viral entry.

Experimental study of tissue-engineered urethra with collagen / chitosan composite as scaffolds

The paper investigates tissue-engineered urethra using collagen/chitosan scaffolds and reports a new method for quantifying epithelial cell activity.

Benefits of commitment in hierarchical inference

The paper quantifies how committing to a single high-level interpretation affects feature-level estimation accuracy in hierarchical inference tasks, finding benefits under certain conditions.

Jagged1/Notch2 Controls Kidney Fibrosis via Tfam-mediated Metabolic Reprogramming

This study identifies Jag1/Notch2 as a key driver of kidney fibrosis through Tfam-mediated metabolic reprogramming in mouse models.

Comprehensive single cell RNAseq analysis of the kidney reveals novel cell types and unexpected cell plasticity

The paper uses single-cell RNA sequencing to identify novel kidney cell types and Notch-mediated plasticity in collecting duct cells, which is defective in chronic kidney disease.