Author

Eshika Arora

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Cell Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

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Angela G. FleischmaniD· 1 shared Brianna HooveriD· 1 shared Eli M. SoyferiD· 1 shared Helen Q. Huang· 1 shared Hew Yeng LaiiD· 1 shared Jane Chen· 1 shared Jianhong C Heidmann· 1 shared Kalei Guillermo· 1 shared

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2025-2025 · peak 1/yr

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Angela G. FleischmanORCID

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1 paper

Recent·Most cited

Cell BiologybioRxivPreprintSep 30, 2025

Impaired IL-10 Receptor Signaling Leads to Inflammation Induced Exhaustion in Hematopoietic Stem Cells

William Lucas P Wadley, Helen Q. Huang, Hew Yeng Lai…·Angela G. Fleischman

This study shows that IL-10 receptor signaling prevents inflammation-induced hematopoietic stem cell exhaustion, and its blockade accelerates aging and promotes clonal expansion of Jak2V617F mutant HSCs.

DOI 10.1101/2025.09.30.679613

mousebulk RNA-seq

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