Angela G. Fleischman

This study shows that cigarette smoke and e-cigarette aerosol extracts suppress inflammatory cytokine production and induce myelopoiesis, leading to hematopoietic aging.

The paper shows that hierarchical tissue structure creates history-dependent barriers to clonal invasion, with established clones affecting the invasion thresholds for subsequent mutants.

This study shows pitavastatin overcomes venetoclax resistance in AML by depleting GGPP, inducing apoptosis through PUMA upregulation and MCL-1 reduction, and suppressing mitochondrial metabolism.

This study shows that IL-10 receptor signaling prevents inflammation-induced hematopoietic stem cell exhaustion, and its blockade accelerates aging and promotes clonal expansion of Jak2V617F mutant HSCs.

This paper develops a multimodal therapy for CML combining computational target analysis with nanoparticle-based drug delivery and validates its efficacy in mouse models.

The paper uses an experimentally parameterized mathematical model to show how hematopoietic stem cells dynamically adjust and resist mutant invasion during steady state hematopoiesis.