Removing the Gβγ-SNAP25 brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity
R. P. Ceddia, Z. Zurawski, A. Thompson Gray, F. Adegboye, A. McDonald-Boyer, F. Shi, D. Liu, J. Maldonado, J. Feng, Y. Li, S. Alford, J. E. Ayala, O. P. McGuinness, S. Collins, H. E. Hamm
This paper shows that disrupting the Gβγ-SNAP25 interaction improves insulin action, promotes adipocyte browning, and protects against diet-induced obesity in mice.
bioRxiv · Apr 29, 2020 · PreprintPhysiology