F. Shi

Immune Checkpoint Blockade Delays Cancer and Extends Survival in Murine DNA Polymerase Mutator Syndromes

This paper shows that immune checkpoint blockade (ICB) can delay cancer onset and improve survival in mice with mutator syndromes, but only if administered prophylactically before tumors develop.

RESPIRATION DEFECTS LIMIT SERINE SYNTHESIS REQUIRED FOR LUNG CANCER GROWTH AND SURVIVAL

This study shows that mitochondrial DNA mutations in NSCLC cause respiration defects, leading to glucose dependency, reduced serine synthesis, and increased cancer survival.

Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy

This study shows that p63 regulates the balance between squamous and neuroendocrine cell fates in esophageal development and cancer by modulating epigenetic mechanisms.

HDAC4-mediated deacetylation of GSDMD prevents pyroptosis by inhibiting GSDMD ubiquitination

This study identifies HDAC4-mediated deacetylation of GSDMD as a mechanism to inhibit pyroptosis by preventing GSDMD ubiquitination.

Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browning

This study identifies SIK3 as a key mediator of β-adrenergic signaling in adipose thermogenesis, showing that its inhibition promotes browning and thermogenic gene expression.

Discovery of another mechanism for the inhibition of particulate guanylyl cyclases by the natriuretic peptide clearance receptor

This paper identifies a new mechanism by which NPRC inhibits NP signaling by forming heterodimers with NPRA or NPRB, preventing cGMP production.

Exercise performance is not improved in mice with skeletal muscle deletion of natriuretic peptide clearance receptor

This study investigates whether enhancing natriuretic peptide signaling in skeletal muscle improves exercise performance in mice, finding no significant improvement in knockout mice.

Diverse Strategies Utilized by Coronaviruses to Evade Antiviral Responses and Suppress Pyroptosis

This study identifies how coronaviruses like PEDV and SARS-CoV-2 evade antiviral responses by manipulating caspase-1 and inhibiting IFN-I signaling through proteolytic activities.

Transcriptome profile and clinical characterization of ICOS expression in brain gliomas

This study examines ICOS expression in gliomas using transcriptome data and clinical information, finding it correlates with malignancy, immune response, and poor prognosis.

E3 ubiquitin ligase SYVN1 is a key positive regulator for GSDMD-mediated pyroptosis

This study identifies SYVN1 as an E3 ubiquitin ligase that promotes GSDMD-mediated pyroptosis by ubiquitinating GSDMD at specific residues.

ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes

The paper presents crystal structures of Drosophila ROR and RYK orthologs, revealing distinct WNT-recognition mechanisms through their extracellular domains.

The nonstructural protein 5 of coronaviruses antagonizes GSDMD-mediated pyroptosis by cleaving and inactivating its pore-forming p30 fragment

This study identifies how coronavirus Nsp5 protein inhibits pyroptosis by cleaving GSDMD, preventing pore formation and viral replication inhibition.

Increased energy expenditure and protection from diet-induced obesity in mice lacking the cGMP-specific phosphodiesterase, PDE9

This study shows that mice lacking PDE9 are resistant to obesity and have increased energy expenditure on a high-fat diet, with improved glucose handling and reduced hepatic steatosis.

Calumenin contributes to epithelial-mesenchymal transition and predicts poor survival in glioma

This study identifies calumenin (CALU) as a marker of poor prognosis in glioma, showing its association with epithelial-mesenchymal transition and malignant phenotypes.

IKBIP is a novel EMT-related biomarker and predicts poor survival in glioma

This study identifies IKBIP as an EMT-related biomarker associated with poor survival in glioma, showing its correlation with aggressive phenotypes and key EMT markers.

Removing the Gβγ-SNAP25 brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity

This paper shows that disrupting the Gβγ-SNAP25 interaction improves insulin action, promotes adipocyte browning, and protects against diet-induced obesity in mice.

Dscam homophilic specificity is generated by high order cis-multimers coupled with trans self-binding of variable Ig1 in Chelicerata

The paper shows that Dscam isoforms in Chelicerata form cis-multimers and trans-self-bind via Ig1 domains to generate unique homophilic recognition specificities for neuronal self-avoidance.

Acute and chronic toxicity assessment of benzylpenicillin G residues in heat-treated animal food products

This study assesses the acute and chronic toxicity of benzylpenicillin G residues in heat-treated animal food products using a mouse model, finding reduced LD50 and organ damage at high exposure levels.