S. Collins

TET2 regulates early and late transitions in exhausted CD8+ T-cell differentiation and limits CAR T-cell function

This study shows that targeting TET2 in CAR T-cells improves their anti-tumor responses by limiting terminal exhaustion and enhancing therapeutic potential.

Wild bird mass mortalities in eastern Canada associated with the Highly Pathogenic Avian Influenza A(H5N1) virus, 2022

The paper estimates 40,966 wild bird mortalities in eastern Canada due to H5N1 avian influenza in 2022, highlighting potential population-level impacts on Northern Gannets and American Common Eiders.

Transposable element insertions are associated with Batesian mimicry in the pantropical butterfly Hypolimnas misippus

This study identifies transposable element insertions at the M locus in Hypolimnas misippus that drive adaptive atavism for Batesian mimicry of Danaus chrysippus.

Enabling Success Through Transformative Practices in STEM: The Effects of Applying an Anti-Deficit Framework to Diversity and Equity Programming

This paper describes how applying an anti-deficit framework to DEI programming in STEM improves student success by focusing on enablers of success rather than challenges.

Trophic flexibility and hydrology structure alpine stream food webs: Implications for a fading cryosphere

The paper examines food web structure in alpine streams with different hydrologic sources, finding that subterranean ice-fed streams support unique diets and may provide critical habitat for cold-water species under climate change.

Scavenging dicarbonyls with 5'-O-pentyl-pyridoxamine increases HDL net cholesterol efflux capacity and attenuates atherosclerosis and insulin resistance

This study shows that scavenging reactive dicarbonyls with PPM reduces atherosclerosis and insulin resistance in Ldlr-/- mice by improving HDL function and reducing inflammation.

Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browning

This study identifies SIK3 as a key mediator of β-adrenergic signaling in adipose thermogenesis, showing that its inhibition promotes browning and thermogenic gene expression.

Rapid reductions in population size drive evolutionary divergence in diatoms

This study shows that population bottlenecks drive transcriptional diversification in diatoms through changes in gene expression patterns, even without environmental change.

Exercise performance is not improved in mice with skeletal muscle deletion of natriuretic peptide clearance receptor

This study investigates whether enhancing natriuretic peptide signaling in skeletal muscle improves exercise performance in mice, finding no significant improvement in knockout mice.

Rapid bilevel optimization to concurrently solve musculoskeletal scaling, marker registration, and inverse kinematic problems for human motion reconstruction

This paper introduces a rapid bilevel optimization method to automate motion capture data processing, reducing manual effort and improving accuracy in biomechanical analysis.

Prophylactic low-dose, bi-weekly benznidazole treatment fails to prevent Trypanosoma cruzi infection in dogs under intense transmission pressure

This study tests low-dose, bi-weekly benznidazole prophylaxis in dogs under high T. cruzi transmission pressure but finds no reduction in new infections.

Glucagon-Like Peptide-1 Receptor Activation Stimulates PKA-Mediated Phosphorylation of Raptor and this Contributes to the Weight Loss Effects of Liraglutide

This study shows that GLP-1R agonist liraglutide induces PKA-mediated phosphorylation of Raptor at Ser791, which contributes to its weight loss effect.

Multitrait diversification in marine diatoms in constant and warmed environments

The paper studies how multiple traits in marine diatoms evolve under constant and warmed environments, finding that trait correlations shift and that multitrait evolution occurs along a major variation axis.

The need for unrealistic experiments in global change biology

The paper argues for more comprehensive experiments on phytoplankton responses to climate change by using multiple levels of temperature and CO2 to better predict future population dynamics.

Epidemiological dynamics of viral infection in a marine pico-eukaryote

The paper uses epidemiological models to show that periodic viral re-seeding, not resistance costs, explains the persistence of susceptible hosts in natural populations of Ostreococcus tauri.

Single cell transcriptome mapping identifies a local innate B cell population driving local antibody production and chronic rejection after lung transplantation

The paper identifies a local innate B cell population that drives antibody production and chronic rejection in lung transplants using single-cell transcriptomics.

PDE9 Inhibition Activates PPARa to Stimulate Mitochondrial Fat Metabolism and Reduce Cardiometabolic Syndrome

This study shows PDE9 inhibition activates PPARa to enhance mitochondrial fat metabolism and reduce cardiometabolic syndrome in mice, with potential for treating obesity in men and postmenopausal women.

Increased energy expenditure and protection from diet-induced obesity in mice lacking the cGMP-specific phosphodiesterase, PDE9

This study shows that mice lacking PDE9 are resistant to obesity and have increased energy expenditure on a high-fat diet, with improved glucose handling and reduced hepatic steatosis.

The role of changes in environmental quality in multitrait plastic responses to environmental and social change in the model microalga Chlamydomonas reinhardtii.

This study examines how changes in environmental quality affect intraspecific trait variation in Chlamydomonas reinhardtii, finding higher phenotypic variability in ameliorated environments.

Surviving heatwaves: thermal experience predicts life and death in a Southern Ocean diatom

This study examines how thermal experience and heatwave intensity affect survival and growth in a Southern Ocean diatom under simulated marine heatwaves.

The evolution of trait correlations constrains phenotypic adaptation to high CO2 in a eukaryotic alga

The paper shows that historical trait correlations affect adaptation rates and phenotypes in Chlamydomonas under high CO2, highlighting the need for ecological models to account for trait correlations.

Removing the Gβγ-SNAP25 brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity

This paper shows that disrupting the Gβγ-SNAP25 interaction improves insulin action, promotes adipocyte browning, and protects against diet-induced obesity in mice.

Whole-chromosome hitchhiking driven by a male-killing endosymbiont

The paper investigates the origin and spread of a neo-W chromosome in Danaus chrysippus, showing it hitchhiked with a male-killing Spiroplasma endosymbiont due to suppressed recombination.

Quality-quantity tradeoffs drive functional trait evolution in a model microalgal climate change winner

The paper evolves microalgae in ameliorated environments to study how functional traits change over time, finding a quality-quantity tradeoff in carbon allocation affecting growth and ROS tolerance.

Individual variation of the masticatory system dominates 3D skull shape in the herbivory-adapted marsupial wombats

This study shows that individual variation in the masticatory system dominates 3D skull shape in wombats, challenging the idea that allometry primarily drives shape variation in marsupials.

Diverse strategies link growth rate and competitive ability in phytoplankton responses to changes in CO2 levels

The paper shows that different phytoplankton lineages have unique growth strategies that change in the presence of others, affecting assemblage composition and challenging predictions based on isolated growth rates.

Hitting a moving target: Microbial evolutionary strategies in a dynamic ocean

This study examines microbial evolutionary strategies in a dynamic ocean, finding that variable environments favor a low-β strategy with rapid short-term responses but delayed genetic adaptation.

Connecting the legs with a spring improves human running economy

A spring connecting human legs improves running economy by 6.4% through a complex mechanism affecting both swing and stance phases of gait.