The Hedgehog receptors PTCH1 and PTCH2 exist as active homomeric and heteromeric complexes
A. J. Timmis, F. Cross, D. S. Gkotsi, H. Ollerton, C. A. Johnson, N. A. Riobo-Del Galdo
This study shows PTCH1 and PTCH2 form active homomeric and heteromeric complexes, with PTCH2 having minimal cholesterol transport but essential cation transport residues, and heteromers can compensate for mutations.
bioRxiv · Aug 8, 2023 · PreprintBiochemistry