M. Xia

Methyltransferase DNMT3B promotes colorectal cancer cell proliferation by inhibiting PLCG2

This study identifies DNMT3B as a promoter of colorectal cancer cell proliferation by inhibiting PLCG2 transcription through promoter methylation.

Comparison of Wild-Type and High-risk PNPLA3 variants in a Human Biomimetic Liver Microphysiology System for Metabolic Dysfunction-associated Steatotic Liver Disease Precision Therapy

This study uses a human liver microphysiology system to compare the effects of PNPLA3 variants on MASLD progression and drug response.

The first discovery of SFTSV in the Centre of Metropolitan Beijing, China

This study identifies SFTSV circulation in central Beijing by surveying ticks and hedgehogs, revealing high seroprevalence and RNA prevalence in urban areas.

A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models

This study identifies tonic activation of the cGAS-STING and IFN pathways in ACE2-positive airway cells as a factor limiting SARS-CoV-2 replication.

No evidence for enhanced disease with polyclonal SARS-CoV-2 antibody in the ferret model.

This study tests if polyclonal SARS-CoV-2 antibodies enhance disease in ferrets, finding no significant differences in symptoms or viral shedding between antibody-treated and control groups.

Scalable, flexible carbon fiber electrode thread arrays for three-dimensional spatial profiling of neurochemical activity in deep brain structures of rodents

This paper introduces a flexible carbon fiber electrode-thread array for recording dopamine activity in multiple deep brain targets in rodents and demonstrates its spatial resolution and integration with histological analysis.

Cooperative super-enhancer inactivation caused by heterozygous loss of CREBBP and KMT2D skews B cell fate decisions and yields T cell-depleted lymphomas

This study shows that combined loss of CREBBP and KMT2D disrupts super-enhancer function in B cells, leading to immune evasion and T cell depletion in lymphomas.

Moderate High Temperature is Beneficial or Detrimental Depending on Carbon Availability in the Green Alga Chlamydomonas reinhardtii

This study shows that moderate high temperature (35°C) benefits Chlamydomonas reinhardtii growth with acetate but harms it without, highlighting carbon metabolism's role in thermotolerance.

Microbiota-stimulated Interleukin-22 regulates brain neurons and protects against stress-induced anxiety

This study identifies IL-22 as a key immune-to-brain signal that reduces stress-induced anxiety by acting on septal neurons.

Quantitative bioactivity signatures of dietary supplements and natural products

The paper screens dietary supplements and natural products for bioactivity using in vitro assays and predicts their mechanisms of action by comparing activity profiles with approved drugs.

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology

This paper describes an in vivo qHTS method using C. elegans to assess drug toxicity and therapeutic potential, demonstrating its feasibility with anti-infective agents and toxicological compounds.

Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis

This study creates a human fetal cerebellar cell atlas to identify transitional progenitors linked to aggressive medulloblastoma subgroups and their oncogenic mechanisms.

The SARS-CoV-2 spike protein binds and modulates estrogen receptors

This study identifies a novel interaction between SARS-CoV-2 spike protein and estrogen receptor alpha, showing its role in modulating ER activity and ACE2 expression in infected cells and tissues.

Novel Murine models of Mania and Depression

This paper develops a novel murine model of mania through environmental stressors and validates it against depression models and controls.

Common and lifestyle-specific traits of mycorrhiza-associated metabolite alterations in plant roots reflects strategies of root-mycorrhizal interactions

This study identifies common and lifestyle-specific metabolite changes in plant roots associated with mycorrhizal fungi, revealing strategies for carbon partitioning and specialized metabolism in different mycorrhizal lifestyles.

Comparative Phenotyping of Two Commonly Used Chlamydomonas reinhardtii Background Strains: CC-1690 (21gr) and CC-5325 (the CLiP Mutant Library Background)

This study compares the phenotypes of two Chlamydomonas reinhardtii strains, CC-1690 and CC-5325, revealing differences in growth, photosynthesis, cell wall, and circadian rhythms.

METTL3 promotes homologous recombination repair and modulates chemotherapeutic response by regulating the EGF/Rad51 axis

This study identifies METTL3's role in promoting homologous recombination repair and modulating chemotherapeutic response in breast cancer cells by regulating the EGF/RAD51 axis through m6A modification.

Systems-wide Analysis Revealed Shared and Unique Responses to Moderate and Acute High Temperatures in the Green Alga Chlamydomonas reinhardtii

This study identifies shared and unique cellular responses to moderate and acute high temperatures in Chlamydomonas reinhardtii, revealing mechanisms for thermotolerance.

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and prolonged shedding of infectious virus from both respiratory and gastrointestinal tracts

An Integrated Systems Biology Approach Identifies the Proteasome as a Critical Host Machinery for ZIKV and DENV Replication

The paper identifies the proteasome as critical for ZIKV and DENV replication through three systems biology approaches and finds proteasome inhibitors suppress both viruses.

Long noncoding RNA AVAN promotes antiviral innate immunity by interacting with TRIM25 and enhancing the transcription of FOXO3a

This study identifies lncRNA AVAN as a positive regulator of antiviral innate immunity by interacting with TRIM25 and enhancing FOXO3a transcription.

Comparative transcriptomics reveal that adaptive evolution in immune genes drives the local adaptation and speciation of schizothoracine fish

This study identifies immune-related genes under positive selection in schizothoracine fish, linking their adaptive evolution to speciation and local adaptation on the Qinghai-Tibetan Plateau.