Sonic hedgehog medulloblastoma cells in co-culture with cerebellar organoids converge towards in vivo malignant cell states
M. J. van Essen, A. Nicheperovich, B. Schuster-Boeckler, E. Becker, J. Jacob
This study shows SHH-MB cells in co-culture with cerebellar organoids adopt patient tumor-like phenotypes and heterogeneity, suggesting microenvironment-driven malignant states.
bioRxiv · Apr 1, 2024 · PreprintCancer Biology