ROCK1 activates mitochondrial fission leading to oxidative stress and muscle atrophy
M. Si, R. Yu, H. Lin, F. Li, S. Y. Jung, S. Thomas, F. Danesh, Y. Wang, H. Peng, Z. Hu
This study identifies ROCK1 activation as a driver of mitochondrial fission and oxidative stress in CKD-induced muscle wasting, showing pharmacological inhibition of ROCK1 can alleviate these effects.
bioRxiv · Oct 22, 2023 · PreprintCell Biology