Z. Hu

Endomucin regulates the endothelial cytoskeleton independent of VEGF

This study shows that endomucin regulates endothelial cytoskeleton dynamics in angiogenesis independently of VEGF signaling.

Deletion of the endothelial glycocalyx component endomucin leads to impaired glomerular structure and function

This study shows that deleting endomucin in endothelial cells causes structural and functional issues in kidney glomeruli, including podocyte damage and albuminuria.

Endomucin knockout leads to delayed retinal vascular development and reduced ocular pathological neovascularization

This study shows that Endomucin deficiency delays retinal vascular development and reduces pathological neovascularization in mouse models.

scCancerExplorer: a comprehensive database for interactively exploring single-cell multi-omics data of human pan-cancer

scCancerExplorer provides an interactive database for exploring single-cell multi-omics data across 50 cancer types, integrating genomic, epigenomic, and transcriptomic data.

Label-free visualization of ciliary rootlets in mouse brain

This paper introduces a label-free imaging method to visualize ciliary rootlets in mouse brain tissue, revealing their organized distribution and formation timing relative to primary cilia.

Atomic-scale mechanisms of GDP extraction by SOS1 in KRAS-G12 and KRAS-D12 oncogenes

The paper reveals the atomic mechanisms of GDP extraction by SOS1 from KRAS-G12D and KRAS-D12 oncogenes, identifying key residues and interactions involved.

Lymphoid origin of a lineage of intrinsically activated plasmacytoid dendritic cell in mice and humans

The paper identifies a novel plasmacytoid dendritic cell lineage in mice and humans derived from common lymphoid progenitors, characterized by unique gene expression and functional properties.

Immune Checkpoint Blockade Delays Cancer and Extends Survival in Murine DNA Polymerase Mutator Syndromes

This paper shows that immune checkpoint blockade (ICB) can delay cancer onset and improve survival in mice with mutator syndromes, but only if administered prophylactically before tumors develop.

c-di-GMP modulates ribosome assembly by inhibiting rRNA methylation

This study shows c-di-GMP inhibits rRNA methylation by binding to RlmI, modulates ribosome assembly, and promotes antibiotic tolerance in E. coli.

TNBC response to paclitaxel phenocopies interferon response which reveals cell cycle-associated resistance mechanisms

This study shows paclitaxel response in TNBC mimics interferon response, revealing ELF3 as a biomarker for resistance.

On the discovered Cancer Driving Nucleotides (CDNs)-Distributions across genes, cancer types and patients

This study identifies Cancer Driving Nucleotides (CDNs) across cancer types and patients, finding that most remain unidentified and highlights the need for larger sample sizes to improve detection.

The theory of massively repeated evolution and full identifications of Cancer Driving Nucleotides (CDNs)

This study develops a theory to identify Cancer Driving Nucleotides (CDNs) by analyzing mutation recurrence across large cancer datasets, finding that mutations recurring at least three times are likely CDNs.

Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment

This study identifies PRMT inhibitors as effective combinational therapies with PARP inhibitors to sensitize HR-proficient ovarian and breast cancer cells to treatment.

Changes in Cerebrospinal Fluid Proteins across the Spectrum of Untreated and Treated Chronic HIV-1 Infection

The paper measures CSF proteins in HIV-1 infected and uninfected individuals, identifying patterns of protein changes associated with CNS injury and treatment effects.

Multi-omics delineate growth factor network underlying exercise effects in an Alzheimer's mouse model

The paper investigates how exercise affects Alzheimer's disease in mice by analyzing gene expression and chromatin changes, finding that growth factor signaling pathways are key to exercise's benefits.

Metabolic immaturity of newborns and breast milk bile acids are the central determinants of heightened neonatal vulnerability to norovirus diarrhea

This study identifies metabolic immaturity in newborns and maternal bile acids in breast milk as key factors increasing vulnerability to norovirus diarrhea.

A rat model of cirrhosis with well-differentiated hepatocellular carcinoma induced by thioacetamide

This study develops a rat model of cirrhosis-induced hepatocellular carcinoma using thioacetamide, showing fibrosis, altered liver architecture, and increased AFP levels.

Co-occurrence of Direct and Indirect Extracellular Electron Transfer Mechanisms during Electroactive Respiration in a Dissimilatory Sulfate Reducing Bacterium

This study investigates the extracellular electron transfer (EET) mechanisms in Desulfovibrio vulgaris Hildenborough, revealing both direct and indirect EET pathways and their role in microbial fuel cell performance.

Molecular basis of inhibition of the amino acid transporter B0AT1 (SLC6A19)

This paper identifies high-affinity inhibitors of B0AT1 and elucidates their mechanism of action through cryo-EM structures.

Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing

This study uses scRNA-seq to analyze how chemotherapy remodels the immune landscape and metabolic state in lung adenocarcinoma, identifying changes in macrophage subtypes and immune responses.

RNA Splicing Junction Landscape Reveals Abundant Tumor-Specific Transcripts in Human Cancer

This study analyzes RNA splicing junctions in 34,775 samples to identify 29,051 tumor-specific transcripts linked to cancer stemness, poor prognosis, and immunotherapy targets.

Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination

This study identifies potent and broadly neutralizing antibodies against SARS-CoV-2 and related sarbecoviruses from a vaccinated donor, showing their efficacy against multiple variants and providing insights for therapeutic development.

Feedback loop regulation between viperin and viral hemorrhagic septicemia virus through competing protein degradation pathways

This study identifies a feedback loop between viperin and VHSV where viperin degrades viral proteins via autophagy, while viral N protein suppresses viperin via proteasome degradation.

Modeling Combination Chemo-Immunotherapy for Heterogeneous Tumors

This study develops mathematical models to explore how chemotherapy and immune checkpoint blockade (ICB) combination therapy affects heterogeneous tumors, revealing chemotherapy's role in reducing antigenic heterogeneity and enhancing ICB efficacy through immune recovery.

Control of ciliary transcriptional programs during spermatogenesis by antagonistic transcription factors

This study identifies XAP5 and XAP5L as antagonistic transcription factors that regulate ciliary gene expression during spermatogenesis, with XAP5 promoting and XAP5L inhibiting ciliary transcription factors at different stages.

Auditory High Entropy Response (A-HER): A Novel Paradigm for Studying Brain Processing of Uncertain Information

The paper introduces A-HER, a paradigm that maximizes auditory stimulus entropy to study brain processing of uncertain information, showing improved signal-to-noise ratio and repeatability compared to other methods.

Human Induced Pluripotent Stem Cell based Hepatic-Modeling of Lipid metabolism associated TM6SF2 E167K variant

This study creates a human iPSC-derived hepatocyte model with the TM6SF2 E167K mutation to study its effects on lipid metabolism and MASLD.

Unbiased Complete Estimation of Chloroplast Number in Plant Cells Using Deep Learning Methods

This paper introduces a deep learning method for accurate 3D chloroplast counting in plant cells, achieving over 95% accuracy compared to manual methods.

An ancient transcription activator is required for the multiciliogenesis program

This study identifies Edf1 as an essential transcription activator for multiciliogenesis, showing its role in ciliary gene expression and its impact on hydrocephalus in mice.

Viral Syncytia Evolve to Resist Interferon

This study shows that SARS-CoV-2 syncytia reduce interferon and antibody effectiveness, explaining the evolution of fusogenic viral variants.