Shifting KRAS hotspot mutations inhibition paradigm in colorectal cancer
A. R. Bras, A. Lopes, N. Mendes, P. J. Costa, A. Ferreira, S. Granja, A. P. Silva, F. Tortosa, F. Baltazar, F. Gartner, M. J. Sousa, A. Valente, A. Preto
This study identifies a ruthenium compound, PMC79, that selectively inhibits KRAS mutations in colorectal cancer and enhances chemotherapy efficacy.
bioRxiv · Aug 9, 2023 · PreprintPharmacology & Toxicology